Viral infections in patients after transplantation and with an immune response disorder
Virové infekce u pacientů po transplantaci a s poruchou imunity
Imunosupresivní léčba po transplantaci kostní dřeně či solidního orgánu a při autoimunitních chorobách vede ke zvýšenému riziku infekčních komplikací. Vzhledem k potlačení T-lymfocytární imunity patří virové infekce mezi nejčastější. Na rozdíl od obecné populace se uplatňují i oportunní patogeny. Dopad virových infekcí zahrnuje i dlouhodobé nepřímé vlivy jako je onkogenní potenciál a imunomodulační efekt s rizikem vzniku dalších oportunních infekcí.
Klíčová slova:
virové infekce, transplantace, imunodeficience.
Authors:
T. Reischig
Authors‘ workplace:
Přednosta: doc. MUDr. Martin Matějovič, Ph. D.
; Lékařská fakulta Universita Karlova
; Fakultní nemocnice, Plzeň
; I. interní klinika
Published in:
Prakt. Lék. 2007; 87(4): 250-252
Category:
Therapy
Overview
Immunosuppression following bone marrow or organ transplantation, or for the treatment of autoimmune diseases, results in an increased susceptibility to infection. Viral infections are the most common because of the suppression of T-lymphocyte immune responses and patients are more prone to opportunistic pathogens. In the longer term, viral infection may also have an impact on oncogenic potential and have an immunomodulatory effect, which may result in further opportunistic infections.
Key words:
viral infection, transplantation, immunodeficiencies.
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2007 Issue 4
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