Hydrophobicity of Klebsiella pneumoniae after Treatment with Ofloxa-cin, Pefloxacin and Tobramycin
Hydrofobicita Klebsiella pneumoniae po účinkuofloxacínu, pefloxacínu a tobramycínu
Študovali sme ovplyvnenie povrchovej hydrofobicity kmeňa Klebsiella pneumoniae po účinkuofloxacínu, pefloxacínu a tobramycínu v subinhibičných koncentráciách (1/4, 1/8 a 1/16 MIC). Tes-tované antibiotiká v koncentračnej závislosti znížili bunkovú povrchovú hydrofobicitu. Najúčinnej-šia redukcia bola zistená po pôsobení 1/4 MIC testovaných antibiotík. Bunková hydrofobicitaúčinkom týchto koncentrácií bola znížená na 44 % (ofloxacín), 50,7 % (pefloxacín) a 56,1 % (tobramy-cín) kontrolných hodnôt.
Klíčová slova:
Klebsiella pneumoniae – povrchová hydrofobicita – ofloxacín – pefloxacín – tobramy-cín – subinhibičné koncentrácie.
Authors:
A. Hoštacká
Authors‘ workplace:
Ústav preventívnej a klinickej medicíny, Bratislava
Published in:
Epidemiol. Mikrobiol. Imunol. , 1999, č. 1, s. 28-30
Category:
Overview
The effect of ofloxacin, pefloxacin and tobramycin at subinhibitory concentrations (1/4, 1/8 and 1/16of the MICs) on surface hydrophobicity of the Klebsiella pneumoniae strain was studied. Theantibiotics tested decreased cell surface hydrophobicity in a dose-dependent manner. The mostsignificant reduction of surface hydrophobicity was found after treatment with antibiotics at 1/4 oftheir MICs. Surface hydrophobicity of K. pneumoniae after exposure to these concentrations wasdecreased to 44% (ofloxacin), 50.7% (pefloxacin) and 56.1% (tobramycin) compared with controls.
Key words:
Klebsiella pneumoniae – cell surface hydrophobicity – ofloxacin – pefloxacin – tobramy-cin – subinhibitory concentrations.
Labels
Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
1999 Issue 1
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