Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics
ENANTIOMÉRNE SEPARÁCIE LIEČIV NA BÁZEMAKROCYKLICKÝCH ANTIBIOTÍK
V prehľadnom referáte sa popisujú vlastnosti vankomycínu, teikoplanínu a ristocetínu A, makrocyklických antibiotík, ktoré sa dajú využiť ako stacionárne fázy na separáciu enantiomérov liečivobsahujúcich stereogénne centrum. Analyzujú sa výsledky, ktoré sa dosiahli pri separácii aminokyselín, ich derivátov, loxiglumidu, clenbuterolu, practololu, carnitínu levodopy, metyldopy, ceftazidí-nu, derivátov kyseliny alkoxyfenylkarbámovej, dichlorpropu, ketoprofenu, warfarinu, námelovýchalkaloidov metódou vysokoúčinnej kvapalinovej chromatografie (HPLC)
Klíčová slova:
vankomycín - teikoplanín - ristocetín A - stacionárne fázy - vlastnosti -delenie enantiomérov - HPLC
Authors:
T. Rojkovičová; J. Lehotay; J. Čižmárik
Authors‘ workplace:
Katedra analytickej chémie Chemickotechnologickej fakulty Slovenskej technickej univerzity, Bratislava, Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 2001; , 166-172
Category:
Overview
The present review paper describes the properties of the macrocyclic antibiotics vancomycin,teikoplanin, and ristocetin A, which can be used as stationary phases for separation of theenantiomers of drugs containing a stereogenic centre. It analyzes the results obtained in theseparation of amino acids, its derivatives, loxiglumide, clenbuterol, practolol, carnitine, levodopa,methyldopa, ceftazidine, alkoxyphenylcarbamic acid derivatives, dichloroprop, ketoprofen, warfarin, and ergot alkaloids by means of high-performance liquid chromatography (HPLC)
Key words:
vancomycin - teikoplanin - ristocetin A - stationary phases - properties -separation of enantiomers - HPLC
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2001 Issue 4
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