Effect of Losartan on the Antioxidant Status of Rats with Diabetes Mellitus
VPLYV LOSARTANU NA ANTIOXIDAČNÝ STAVPOTKANOV S DIABETES MELLITUS
Predmetom štúdia bolo sledovať vplyv podávania antihypertenzívneho lieku losartanu na:
1) antioxidačny stav potkanov s experimentálnym inzulíndependentnym diabetes mellitus; 2) stav oxidačného poškodenia reprezentovaného tvorbou látok, ktoré reagujú s kyselinou tiobarbiturovou(TBARP) a 3) niektoré metabolické parametre. Podávanie losartanu vyznamne neovplyvnilo koncentráciu glukózy, cholesterolu, triacylglycerolov a kyseliny močovej v plazme kontrolnych a diabetickych zvierat. V pečeňovom tkanive sa po podaní losartanu znízila koncentrácia triacylglycerolov,koncentrácia cholesterolu nebola ovplyvnená. Ďalej sa zistilo, ze podávanie losartanu zvyšilohladinu antioxidantov rozpustnych v lipidoch v plazme diabetickych potkanov, čo môze byš príčinouzisteného znízenia obsahu TBARP v plazme diabetickych potkanov.
Klíčová slova:
antioxidačný stav - losartan - diabetes mellitus - oxidačný stres
Authors:
A. Liptáková; O. Uličná 1; Z. Ďurčková; P. Božek 2; O. Vančová 1
Authors‘ workplace:
Ústav lekárskej chémie, biochémie a klinickej biochémie LF UK, Bratislava, Farmakobiochemické laboratórium III. internej kliniky LF UK, Bratislava, Nemocnica s poliklinikou Ministerstva vnútra, Bratislava
Published in:
Čes. slov. Farm., 2001; , 193-196
Category:
Overview
The aim of this study was to monitor the effect of the administration of antihypertensive druglosartan on: (1) the antioxidant status of rats with experimental insulin-dependent diabetesmellitus; (2) oxidative damage which is represented by the production of compounds which can reactwith thiobarbituric acid (TBARP), and (3) some metabolic parameters. Losartan administration didnot significantly influence the concentration of glucose, cholesterol, triacylglycerol, and uric acid inthe plasma of control and diabetic animals. In the liver tissue, the concentration of triacylglycerolsdecreased after losartan administration, but the concentration of cholesterol did not change. Thepresent authors have found that losartan administration increased the levels of water solubileantioxidants in the plasma of diabetic rats, which can result in a decrease of the TBARP levels inthe plasma of diabetic rats.
Key words:
antioxidant status - losartan - diabetes mellitus - oxidative stress
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2001 Issue 4
- FDA Warns Against Self-Monitoring Glucose Using Smartwatches. What About in Czechia?
- What is the future of xenotransplantation? Pig liver and kidneys transplanted to humans for the first time
- Vitamins in Prevention and Treatment of COVID-19
Most read in this issue
- Phytotherapeutic Aspects of the Diseases of the Circulatory System7. Schisandra chinensis (TURCZ.) BAILL.: Its Constituents and Their Biological Activity
- Advances in the Development of New Antituberculotics from the Group of Ortho--Condensed Heterocyclic CompoundsPart 1. Compounds Containing One Heteroatom in the Six-Membered Ring
- Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics
- Unused Drugs Returned to Pharmacies I.