Analytical Evaluation of the Substance BL 443 Pivalate
ANALYTICKÉ HODNOTENIE LÁTKY BL 443PIVALÁTU
V práci prezentujeme výsledky analytického hodnotenia a štúdia niektorých fyzikálno-chemickýchvlastností nového potenciálneho liečiva typu prodrug O látky BL 443 pivalátu s predpokladanýmantidysrytmickým účinkom. štruktúra látky sa potvrdila elementárnou analýzou, IE a UF spek-troskopiou. Stanovili sme nasledovné parametre: teplotu topenia, rozpustnosť, disociaenú konitantu, experimentálny rozdeľovací koeficient v štyroch rôznych systémoch, povrchovú aktivitu.študovali sme chromatografické správanie sa látky na tenkej vrstve (adsorpená a rozdeľovaciachromatografia). Pre stanovenie obsahu látky v eistej substancii sme použili acidimetrickú titráciuv nevodnom prostredí a spektrofotometriu v ultrafialovej oblasti spektra pri vlnovej dažke druhéhoabsorpeného maxima látky.
Klíčová slova:
prolieèivá - BL 443 pivalát: butylester kyseliny [(2-pivaloyloxy-3-izopropylamino)-propoxy]fenylkarbámovej -analytický profil - fyzikálnochemické vlastnosti
Authors:
Ž. Bezáková; M. Stankovičová; J. Csöllei
Authors‘ workplace:
iv Veterinárnej a farmaceutickej Univerzity, Brno
; Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava, Ústav chemických lieè
Published in:
Čes. slov. Farm., 2001; , 197-202
Category:
Overview
The paper presents the results of an analytical evaluation and a study of some physicochemicalproperties of a new potential drug of the prodrug type Πthe substance BL 443 pivalate with anassumed antidysrhythmic effect. The structure of the substance has been confirmed by elementalanalysis, IR and UV spectroscopy. The following parameters were determined: melting point,solubility, dissociation constant, experimental partition coefficient in four different systems, andsurface activity. The chromatographic behaviour of the drug on a thin layer (adsorption andpartition chromatography) was also investigated. Acidimetric titration in non-aqueous medium andspectrophotometry in the ultraviolet region of the spectrum at the wavelength of the secondabsorption maximum of the drug was employed to determine the content of the drug in puresubstance.
Key words:
prodrug - BL 443 pivalate: butylester of [(2-pivaloyloxy-3-isopropylamino)--propoxy]phenylcarbamic acid - analytical profile - physicochemical properties
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2001 Issue 4
- FDA Warns Against Self-Monitoring Glucose Using Smartwatches. What About in Czechia?
- What is the future of xenotransplantation? Pig liver and kidneys transplanted to humans for the first time
- Vitamins in Prevention and Treatment of COVID-19
Most read in this issue
- Phytotherapeutic Aspects of the Diseases of the Circulatory System7. Schisandra chinensis (TURCZ.) BAILL.: Its Constituents and Their Biological Activity
- Advances in the Development of New Antituberculotics from the Group of Ortho--Condensed Heterocyclic CompoundsPart 1. Compounds Containing One Heteroatom in the Six-Membered Ring
- Enantiomeric Separations of Drugs on the Basis of Macrocyclic Antibiotics
- Unused Drugs Returned to Pharmacies I.