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Safety of Dabigatran in the Secondary Prevention of Venous Thromboembolism in Children

29. 9. 2020 Source: Anticoagulant Treatment

The direct thrombin inhibitor dabigatran is used by adult patients, among others, in the secondary prevention of venous thromboembolism (VTE). Its safety in the pediatric population was the focus of the international phase III study presented below.

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Is It Better to Switch or Cycle in the Treatment of Rheumatoid Arthritis?

The ideal strategy for treating rheumatoid arthritis is still the subject of research. We therefore present the results of a recent study comparing the impact of various therapeutic options when…
24. 9. 2020 Source: Arthritis
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Remarkable Findings from the Subanalysis of the Efficacy and Safety of Teriflunomide in the Chinese Population with MS in Relation to Global Results

Teriflunomide, from the group of disease-modifying drugs (DMDs), intended for the treatment of patients with multiple sclerosis (MS), inhibits the proliferation of lymphocytes. As a result, fewer…
24. 9. 2020 Source: Multiple Sclerosis
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Satisfaction of Patients Treated with Platinum Derivatives with Antiemetic Therapy

The fixed oral combination of netupitant with palonosetron (NEPA) is used for the prevention of nausea and vomiting induced by cytotoxic chemotherapy. A prospective German study evaluated the benefit…
23. 9. 2020 Source: Antiemetic Therapy
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Simple antiemetic prophylaxis for breast cancer patients treated with AC chemotherapy

The combination of an anthracycline cytostatic agent with cyclophosphamide (AC) is among the highly effective chemotherapy regimens for breast cancer. Individually, these cytostatic agents carry a…
23. 9. 2020 Source: Antiemetic Therapy
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Observational Study of Pegylated rVIII Administration in Real Clinical Practice

A recently published article by American hematologists provided valuable information about the treatment with pegylated recombinant factor VIII (rVIII) in real clinical practice. This is the most…
21. 9. 2020 Source: Hemophilia

Cost-effectiveness in Bleeding Control for Acquired Hemophilia A

A pharmacoeconomic analysis showed favorable cost-effectiveness of activated prothrombin complex concentrate in the indication of bleeding control in patients with acquired hemophilia A.
18. 9. 2020 Source: Hemophilia
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Comparison of Efficacy of Bisoprolol and Metoprolol ZOK in Patients with Mild to Moderate Hypertension –⁠ Results of the CREATIVE Study

Suppression of increased activity in the sympathoadrenal system is currently one of the main goals of antihypertensive therapy. Beta-blockers play an important role in regulating the sympathetic…
17. 9. 2020 Source: Cardiovascular Continuum
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Impact of Adequate Protein Intake on Morbidity and Mortality in Critically Ill Patients

The following text provides a summary of findings from clinical studies in the field of nutritional therapy for critically ill patients and its impact on protein metabolism and patient outcomes.
16. 9. 2020 Source: Parenteral Nutrition
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How to Achieve Left Ventricular Reverse Remodeling and Improve Outcomes in Heart Failure? Summary from HFA ESC Webinar

The current treatment algorithm for chronic heart failure with reduced ejection fraction (HFrEF) is well-known to clinicians. But how was its current form developed, and does it have the potential to…
16. 9. 2020 Source: Chronic Heart Failure and Lipidology
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The Importance of Adequate Protein Intake in Critical Patients –⁠ Analysis of Data from an International Study

Adequate protein intake is a necessary part of care for critically ill patients and mitigates catabolic reactions associated with severe illness or injury. The benefits of proper determination and…
16. 9. 2020 Source: Parenteral Nutrition
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Direct Comparison of the Efficacy and Safety of Anti-EGFR Antibodies in the Combined Therapy of Chemotherapy-Refractory Metastatic Colorectal Cancer

The combination of anti-EGFR therapy with irinotecan has brought benefits to patients with chemotherapy-refractory metastatic colorectal cancer (mCRC) in clinical studies. Results of a study directly…
15. 9. 2020 Source: Colorectal Cancer

Glucagon for Intranasal Application Newly Available Also in the Czech Republic

Intramuscular administration of glucagon was until recently the only option for acute treatment of hypoglycemia with impaired consciousness at home. However, since July this year, the Baqsimi product…
15. 9. 2020 Source: Modern Treatment of Diabetes
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Use of Tiapride in the Treatment of Behavioral Disorders in Geriatric Patients

Hand in hand with the increasing number of people reaching an older age, there is also a rise in the occurrence of dementia. It affects the lives of patients and their families in many ways. A…
15. 9. 2020 Source: Geriatric Patient
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Trifluridine/tipiracil, regorafenib, or supportive therapy? Factors affecting the success of mCRC treatment

Currently, there are no biomarkers available to help decide, for a specific patient with refractory metastatic colorectal cancer (mCRC), whether therapy with trifluridine/tipiracil or regorafenib…
15. 9. 2020 Source: Treatment of Gastrointestinal Carcinomas
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