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Fixed Combination of Trastuzumab and Pertuzumab for Subcutaneous Administration in Patients with Early Breast Cancer

25. 10. 2020 Source: Breast Carcinoma

At a symposium focused on breast cancer, held in December 2019 in San Antonio, Texas, preliminary results of the FeDeriCa clinical study were presented –⁠ comparing the pharmacokinetics, efficacy, and safety of a fixed combination of trastuzumab and pertuzumab for subcutaneous administration versus intravenous administration in patients with early-stage HER2-positive breast cancer. Based on the presented results, the drug received approval from the U.S. Food and Drug Administration (FDA).

Dysregulation of microRNA Expression After Treatment with Anti-EGFR Antibodies

A team of researchers from Plzeň decided to verify whether treatment with anti-EGFR antibodies changes the expression of selected microRNAs in patients with metastatic colorectal carcinoma (mCRC).…

22. 10. 2020 Source: Colorectal Cancer

Panitumumab in 1st Line in Older Patients –⁠ Results of the PANDA Study

The phase II PANDA study evaluated the regimens FOLFOX + panitumumab versus 5-FU + panitumumab in the 1st line treatment of patients with wt-RAS/BRAF metastatic colorectal cancer (mCRC).

22. 10. 2020 Source: Colorectal Cancer

Dupilumab in the Treatment of Severe Asthma in Real-World Practice

A freshly published French study is the first to confirm the results of clinical trials with dupilumab in patients with severe asthma in real-world practice.

20. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Treatment of Comorbidities of Atopic Dermatitis in One Go and Where to Refer Candidates for Biologic Therapy

Patients suffering from atopic dermatitis (AD) along with allergic comorbidities typically require a fairly complex pharmacotherapy to manage their difficulties. However, their everyday lives can be…

19. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Metformin −⁠ A Proven Helper That Effectively Protects the Heart of Diabetics

Metformin is one of the first-line medications for patients with type 2 diabetes. In addition to lowering blood glucose levels, it also affects other metabolic processes in the human body. Its…

19. 10. 2020 Source: Modern Treatment of Diabetes

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Prescription Restrictions on Antidiabetics Authorized for Prescription by General Practitioners -⁠ Status as of October 2020

Diabetes mellitus (DM) has become an increasing problem worldwide in recent years. Long-term complications of DM lead to increased morbidity and mortality in the diabetic population, and their…

15. 10. 2020 Source: Diabetes

Obeticholic Acid in the Treatment of Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid in Real Practice

An interim analysis of the OCARELIFE observational study presented at the European Association for the Study of the Liver (EASL) congress in August 2020 attempted to evaluate whether the safety and…

14. 10. 2020 Source: Primary Biliary Cholangitis

Nutritional Care as Part of Prehabilitation in Surgical Patients

Nutritional preparation of patients before surgery as part of prehabilitation can significantly affect the quality of recovery and physical condition of patients after surgery. This topic is…

14. 10. 2020 Source: Enteral Nutrition

Memantine and Donepezil –⁠ Unity is Strength

Memantine and donepezil are both used in the therapy of Alzheimer's disease (AD). However, how does the combination of these drugs fare in the treatment of moderate to severe AD?

12. 10. 2020 Source: Cognitive in the treatment of Alzheimer's disease

Memantine Eases Daily Life for Patients and Caregivers

What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?

12. 10. 2020 Source: Cognitive in the treatment of Alzheimer's disease

What impact do the symptoms of primary biliary cholangitis have on the patient and their quality of life

Primary biliary cholangitis (PBC) is a serious chronic cholestatic autoimmune liver disease that predominantly affects middle-aged women and can lead to end-stage liver failure and the need for…

12. 10. 2020 Source: Primary Biliary Cholangitis

Use of Targeted Therapy with Dupilumab in Patients with Allergic Diseases

Interleukins (IL) 4 and 13 play an important role in the pathogenesis of allergic diseases. Their blockade is therefore a suitable strategy for a number of these conditions. This is offered by the…

11. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

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Fixed Combination of Tramadol/Paracetamol in the Treatment of Chronic Lower Back Pain and Its Effect on Apathy in Chronically Algic Patients

Long-term chronic pain is associated with apathy, loss of motivation, and depression in patients. However, these comorbidities of chronic pain and their interconnections are still insufficiently…

9. 10. 2020 Source: Pharmacotherapy of Pain

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Can the Fixed Combination of Tramadol/Acetaminophen Significantly Reduce Back Pain Uncontrolled by NSAIDs?

One way to prevent drug-related complications in the treatment of lower back pain (LBP) while improving patients' functioning in daily activities is the prescription of the weak opioid agonist…

9. 10. 2020 Source: Pharmacotherapy of Pain

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