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Memantine Eases Daily Life for Patients and Caregivers

12. 10. 2020 Source: Cognitive in the treatment of Alzheimer's disease

What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?

What impact do the symptoms of primary biliary cholangitis have on the patient and their quality of life

Primary biliary cholangitis (PBC) is a serious chronic cholestatic autoimmune liver disease that predominantly affects middle-aged women and can lead to end-stage liver failure and the need for…

12. 10. 2020 Source: Primary Biliary Cholangitis

Use of Targeted Therapy with Dupilumab in Patients with Allergic Diseases

Interleukins (IL) 4 and 13 play an important role in the pathogenesis of allergic diseases. Their blockade is therefore a suitable strategy for a number of these conditions. This is offered by the…

11. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

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Fixed Combination of Tramadol/Paracetamol in the Treatment of Chronic Lower Back Pain and Its Effect on Apathy in Chronically Algic Patients

Long-term chronic pain is associated with apathy, loss of motivation, and depression in patients. However, these comorbidities of chronic pain and their interconnections are still insufficiently…

9. 10. 2020 Source: Pharmacotherapy of Pain

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Can the Fixed Combination of Tramadol/Acetaminophen Significantly Reduce Back Pain Uncontrolled by NSAIDs?

One way to prevent drug-related complications in the treatment of lower back pain (LBP) while improving patients' functioning in daily activities is the prescription of the weak opioid agonist…

9. 10. 2020 Source: Pharmacotherapy of Pain

Brentuximab Vedotin and Relapsing/Refractory NHL with High Expression of CD30

A recently published study by authors from South Korea focused on examining the efficacy of brentuximab vedotin in patients with non-Hodgkin lymphomas (NHL) that highly express CD30 (i.e., > 30%…

7. 10. 2020 Source: Hematologic Malignancies

New Natural Method for Prevention and Treatment of House Dust Mite Allergy

House dust mites are among the most common triggers of respiratory allergies. Until now, therapy has primarily focused on alleviating allergy symptoms. The aim of the new natural-based method is to…

6. 10. 2020 Source: Dust Mite Allergy

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Comparison of Pharmacological Properties of Micronized Diosmin and Hesperidin in the Treatment of Chronic Venous Insufficiency and Hemorrhoids

Diosmin and hesperidin belong to the group of bioflavonoids, which currently find wide application in the treatment of chronic venous insufficiency and hemorrhoidal disease. Both flavonoids have been…

6. 10. 2020 Source: Venous Insufficiency

Topically administered tacrolimus does not increase cancer risk in children with atopic dermatitis

Topical therapy using corticosteroids or calcineurin inhibitors forms the main component of treating atopic dermatitis (AD) in children and adolescents. Although these medications are applied…

6. 10. 2020 Source: Topical Treatment of Psoriasis

Are Topical Calcineurin Inhibitors Really Such Demons?

Some medications indeed have significant side effects, while others suffer from a bad reputation that is hard to dispel. Can we do something reasonable against this? Let's revisit or expand our…

6. 10. 2020 Source: Topical Treatment of Psoriasis

Case Study of a Patient with NSCLC −⁠ with Voting

Presented by: MUDr. Leona Koubková, Pneumology Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague

5. 10. 2020 Source: Immunotherapy in Oncology

Dupilumab –⁠ The First Biologic Umbrellaing Type 2 Inflammation Treatment: How Does It Work and Who Is It For?

A new drug is entering the market for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps –⁠ the biologic product Dupixent®. The active ingredient is dupilumab, a…

5. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Interaction of the 'Big Five' Helps Predict Depression

Experts refer to the 'Big Five' as a personality model that encompasses the following five dimensions: openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism. Can…

5. 10. 2020 Source: Depression and Anxiety

Effect of 3 Different Doses of Trazodone on QT Interval Length

Patients diagnosed with depression often also suffer from cardiovascular diseases, including heart failure. Given the increased risk of death in such comorbid patients, the safety and efficacy of the…

5. 10. 2020 Source: Depression and Anxiety

What Did the Patent for the Synthesis of Highly Purified Trazodone Bring?

Trazodone is a modern antidepressant that is used in the treatment of various types of depression, including those accompanied by anxiety, sleep disorders, or sexual dysfunction. Angelini's…

5. 10. 2020 Source: Depression and Anxiety

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