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Influence of ARNI on the Efficacy and Safety of Empagliflozin in the Treatment of Heart Failure with Reduced Ejection Fraction
Pharmacological inhibition of neprilysin and the AT1 receptor for angiotensin II (ARNI) through sacubitril/valsartan reduces cardiovascular (CV) mortality and the risk of hospitalization for heart failure. The same benefit has also been demonstrated with the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i), also known as gliflozins. A pre-specified sub-analysis of the EMPEROR-Reduced study evaluated whether the benefit of SGLT2i is also significant in patients treated with ARNI.
Autonomic Dysfunction in Patients with Transthyretin Amyloidosis
Autonomic nervous system disorders are a common complication of transthyretin amyloidosis. Their…
Overview of Current Treatment Options for MRSA-Induced Pneumonia
Pneumonia caused by methicillin-resistant strains of Staphylococcus aureus (MRSA) remains a disease…
Postoperative Bleeding in Children with Hypofibrinogenemia Induced by Cardiopulmonary Bypass
Patients undergoing cardiac surgery with the use of cardiopulmonary bypass are at risk of up to a…
Experiences with the Treatment of Coagulopathy in Obstetrics – ROTEM-Guided Algorithm
An observational study from a hospital in Liverpool, UK, was published in the journal Anaesthesia,…
Incidence and Risk Factors of Community-Acquired Pneumonia in Hematologic Oncologic Patients
Patients with hematologic malignancies are at higher risk of infectious diseases, particularly…
Summary of New American Recommendations for Heart Failure Management
This year, the American Heart Association (AHA), the American College of Cardiology (ACC), and the…
Full Compensation of Seizures as the Main Goal of Epilepsy Therapy: Will Patients Achieve It More Easily Than 20 Years Ago?
What is the relationship between the quality of life of patients and the degree of seizure…
Safety Profile of Metamizole – A Systematic Review
Metamizole is a long-established non-steroidal analgesic used for acute and chronic pain…
Early and effective treatment of PBC significantly reduced the need for liver transplantation due to this disease
Current European and Czech guidelines include obeticholic acid (OCA) as the only registered option…