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Pharmacotherapy of Chronic Heart Failure with Reduced EF LV -⁠ Latest ESC Recommendations

22. 11. 2021 Source: Chronic Heart Failure and Lipidology

The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment of heart failure. We summarize the essential points regarding the pharmacotherapy of chronic heart failure with reduced ejection fraction.

Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures

The possibility of actively preventing severe bleeding after a major cardiac surgical procedure using cardiopulmonary bypass (CPB) by administering a concentrate of activated procoagulant complex…

22. 11. 2021 Source: Hemophilia

Neutralizing Antibodies Against Emicizumab –⁠ Detailed Analysis Based on a Case Study

Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient with hemophilia A and an inhibitor, whose treatment was discontinued due to repeated bleeding…

22. 11. 2021 Source: Hemophilia

HAE and its Management in Pediatric Patients

Hereditary angioedema (HAE) can be encountered in the emergency room as well as in specialist practices. Patients with this rare disease are often incorrectly diagnosed with other, more common conditions,...

19. 11. 2021 Source: Hereditary Angioedema

HAE in the Otolaryngologist's Office: How to Handle a Laryngeal Attack?

Hereditary angioedema (HAE) can be encountered in emergency rooms and specialist offices. Patients with this rare disorder are often misdiagnosed with a more common condition, and they may learn their...

19. 11. 2021 Source: Hereditary Angioedema

Cell-Based Implant as a Stable System for Biological Therapy Delivery

A team of scientists from Washington University in St. Louis focused on the possibility of delivering biological inhibitors for the treatment of rheumatoid arthritis using modified induced…

19. 11. 2021 Source: Arthritis

Comparable Long-term Safety of Tofacitinib and Biologics in RA Treatment –⁠ Data from a US Registry

An analysis of the long-term safety profile of tofacitinib in real clinical practice was published in the journal of the American College of Rheumatology (ACR). Patients with rheumatoid arthritis…

18. 11. 2021 Source: Arthritis

Webinář SGLT2i v ESC HF Guidelines vs. reálná praxe

Webinar SGLT2i in ESC HF Guidelines vs. Real Practice

Dear Doctor, Boehringer Ingelheim, in collaboration with the 2nd Department of Internal Medicine -⁠ Department of Cardiology and Angiology, General University Hospital and 1st Faculty of Medicine,…

18. 11. 2021 Source: Heart Failure

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Mechanisms of Cardioprotective Effects of SGLT2 Inhibitors

Inhibitors of sodium-glucose cotransporter 2 (SGLT2i, gliflozins) are a relatively new group of medications used in the treatment of type 2 diabetes mellitus (T2DM). Their clinical use is supported…

18. 11. 2021 Source: Heart Failure

Summary of Guidelines for the Diagnosis, Prevention, and Treatment of Invasive Fungal Infections in Pediatric Patients with Leukemia and Post Hematopoietic Stem Cell Transplantation

Invasive fungal diseases are a significant cause of morbidity and mortality among immunocompromised pediatric patients with leukemia and post-hematopoietic stem cell transplantation. During the 8th…

18. 11. 2021 Source: Anti-Infectives

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Basic Cardiovascular Benefits of the Oral Antidiabetic Medication Empagliflozin

Type 2 diabetes mellitus is one of the main risk factors for cardiovascular (CV) diseases. Empagliflozin is among the modern oral antidiabetic medications, and in 2015 it became a pioneer among…

18. 11. 2021 Source: Heart Failure

Reversal of Dabigatran Effects with Idarucizumab in Patients Requiring Urgent Procedures: Subanalysis of the RE-VERSE AD Study

The effect of idarucizumab as a reversal agent in patients treated with dabigatran in situations requiring urgent surgery or other invasive procedures was evaluated in a subanalysis from the RE-VERSE…

18. 11. 2021 Source: Anticoagulant Treatment

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Safety of Dabigatran According to a Meta-Analysis of 7 Randomized Controlled Trials

Dabigatran is a direct thrombin inhibitor from the group of direct oral anticoagulants (DOACs), developed as an alternative to vitamin K antagonists. The aim of the recently published meta-analysis…

18. 11. 2021 Source: Anticoagulant Treatment

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Efficacy and Safety of Dual Bronchodilator Therapy for COPD –⁠ From Randomized Clinical Trials to Real-World Clinical Practice

Dual bronchodilator therapy (LAMA + LABA) represents one of the mainstays of treating chronic obstructive pulmonary disease (COPD). The aim of the recent systematic review presented below was to…

18. 11. 2021 Source: Treatment of Asthma and COPD

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Epidemiology, Pathophysiology, Diagnosis, and Treatment of Heart Failure in Patients with Diabetes

The proven benefit of one class of antidiabetic drugs –⁠ sodium-glucose cotransporter 2 inhibitors (SGLT2i; gliflozins) –⁠ in treating heart failure irrespective of diabetes presence, and their…

18. 11. 2021 Source: Cardiovascular Continuum

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