Effects of Hormonal Replacement Therapy on the Cardiovascular System
VPLYV HORMONÁLNEJ SUBSTITUČNEJ LIEČBY NAKARDIOVASKULÁRNY APARÁT
Hormonálna substitučná liečba je stále frekventnejšie používanou v období peri a postmenopauzy. Ovplyvňujekauzálnym spôsobom klimakterický syndróm, priaznivo ovplyvňuje psychiku, kvalitu pokožky, znižuje suchosťslizníc, frekventnosť zápalov očí a pošvy. Z dlhodobých účinkov dominuje priaznivý vplyv na kostný metabolizmus,a tým i na výskyt osteoporózy, dlhodobá hormonálna substitúcia redukuje výskyt Alzheimerovej choroby a kolorek-tálneho karcinómu. Estrogény zásadnym spôsobom ovplyvňujú aj kardiovaskulárny systém. Majú priaznivý vplyvna lipidové spektrum, ale za viac ako 50 % benefitu terapie je zrejme zodpovedný priamy vazodilatačný účinok.Estrogénna substitúcia je v mnohých krajinách indikovaná v primárnej prevencii ischemickej choroby srdca a otázkapoužitia tejto liečby v sekundárnej prevencii zostáva otvorená.
Klíčová slova:
estrogény, gestagény, ateroskleróza, ischemická choroba srdca.
Authors:
J. Payer
Authors‘ workplace:
I. interná klinika LF UK a FN, Bratislava
Published in:
Čas. Lék. čes. 1999; : 67-69
Category:
Overview
Hormonal replacement therapy becomes frequently used in peri- and postmenopausal women. It causally affectsthe climacteric syndrome, positively stimulates psychics, improves quality of the skin, decreases dryness of mucousmembranes and frequency of recurrent inflammations of eyes and vagina. The positive influence on the bonemetabolism and therefore on the incidence of osteoporosis highly dominates among its long-term effects. Longlasting hormonal replacement reduces also the incidence of Alzheimer disease, colorectal carcinoma and it hasparticularly favourable effect on the cardiovascular system. Estrogens positive affect the lipid spectrum, however,more than 50 % of their beneficial influence comes from their direct vasodilatory effect. Estrogene replacementbecomes in many countries indicated for the primary prevention of the ischemic heart disease. The question of itsapplication for the secondary prevention remains still open.
Key words:
estrogens, progestins, arteriosclerosis, ischemic heart disease.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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