Genetic background of sarcoidosis
Genetický základ sarkoidózy
V práci je podán přehled současných znalostí týkajících se genetiky sarkoidózy. Studiumkandidátních genů a nově i pátrání v celém genomu zatím nevedly k přesvědčivým průkazůmgenetických abnormalit podílejících se na vzniku onemocnění. S rostoucími možnostmi molekulárnígenetiky lze v blízké budoucnosti očekávat další pokroky v této oblasti.
Klíčová slova:
sarkoidóza - kandidátní geny - mikrosatelity - genetika.
Authors:
J. Homolka; V. Votava; A. Slováková
Authors‘ workplace:
I. klinika TRN 1. LF UK a VFN, Praha, přednosta prof. MUDr. J. Homolka, DrSc.
Published in:
Prakt. Lék. 2004; (4): 186-187
Category:
Overview
Authors discuss briefly the genetic background in sarcoidosis. There are two main principles ofstudying the possible link between sarcoidosis and genes, the analysis of candidate genes orgenomic screening by using microsatellite markers.Up to now there is no direct proof of possiblegenetic abnormalities in sarcoidosis. With increasing potential of molecular genetics furtherprogress in this area can be expected.
Key words:
sarcoidosis - candidate genes - microsatellites - genetics.
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
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