SUPER Trial (Superiority of 24-hour Antihypertensive Effectiveness of Perindopril in Patients with Mild to Moderate Hypertension) Formerly Treated with Enalapril

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Superiorita 24hodinove antihypertenzni ucinnosti perindoprilu u pacientu s mirnou az stredne tezkou hypertenzi drive lecenych enalaprilem

Primarnim cilem 3mesicni studie SUPER bylo potvrzeni ucinnosti lecby ACE inhibitorem perindoprilem v davce 4 mg jednou denne u pacientu drive lecenych enalaprilem v monoterapii podavanym pouze jednou denne po dobu alespofi 3 mesicu, u pacientu s mirnou az stredne tezkou hypertenzi a nedostatecnou 24hodinovou kontrolou krevmho tlaku, zjistenou doma merenym krevnim tlakem.Perindopril vedl k normalizaci krevniho tlaku na konci davkovaciho obdobi u vice nez 50 % nemocnych, drive lecenych enalaprilem podavanym jen jednou denne, kteri meli sice kazualni krevni tlak normalizovany, avsak po 24 hodinach byl krevni tlak neuspokojive kontrolovan. Lecba perindoprilem byla nemocnymi dobre snasena.Enalapril je nutne davkovat 2krat denne. Existuje inhibitory ACE, ktere je mozne davkovat jednou denne, ale enalapril mezi ne nepatri. Patfi mezi ne napr. perindopril, ramipril, trandolapril, fosinopril a dalsi.Screeningova cast studie prokazala, ze monoterapii enalaprilem podavanym 2krat denne bylo leceno 191, tj. 32,7 % ze vsech sledovanych pacientu. Z techto 191 nemocnych melo kazualni krevni tlak kontrolovan (

Klíčová slova:

Authors: Wfd Msky J.'; Balazovjech . ^{1 2}; A. Cerna ³; M. Sachová ³
Authors‘ workplace: ISubkatedra kardiologie IPVZ, prednosta prof. MUDr. V. Stanek, CSc., Klinika kardiologie IKEM, Praha, prednosta doc. MUDr. J. Kautzner, CSc. ZIL interred klinika LFUK a FN Bratislava 3Servier Praha
Published in: Prakt. Lék. 2003; (4): 197-202
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Overview

The primary objective of the 3-month SUPER trial was to confirm the effectiveness of treatment with the ACE inhibitor perindopril, 4 mg o.d., in patients formerly treated with enalapril in monotherapy administered only o.d. for at least three months - patients with mild to moderate hypertension and inadequate 24-hour control of the blood pressure assessed by BP measured at home.Perindopril led to normalization of the blood pressure at the end of the dosage period in more than 50% patients previously treated with enalapril administered only o.d. who had a normalized casual blood pressure, however, after 24 hours the blood pressure was not controlled satisfactorily. Perindopril treatment was well tolerated by the patients.Enalapril must be administered b.i.d. There are ACE inhibitors which can be administered o.d. but enalapril is not among them. They include e.g. perindopril, ramipiril, trandolapril, fosinopril and others.The screening part of the trial proved that enalapril monotherapy administered b.i.d. was the treatment received by 192, i.e. 32.7% of all screened patients. Of these 191 patients 32.5% had a controlled casual blood pressure (>140/90 mm Hg) and 129 (67.5%) had after enalapril monotherapy administered b.i.d. an uncontrolled BP (i.e. the BP was not lower than 140/90 mm Hg). It is of interest that a significant part of these patients was treated for a prolonged period by enalapril monotherapy. From this ensues that combined treatment of hypertension is little used by some general practitioners. As to ACE inhibitor in case of its ineffectiveness a small dose of thiazide diuretic or long-acting calcium channel blocker can be added.

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