Treatment of Depression in Menopausal Women
Léčba depresí v menopauze
V retrospektivní studii byly hodnoceny terapeutické účinky antidepresiv selektivně inhibujících zpětné vychytávání serotoninu (SSRI) u 52 žen v menopauze, které trpěly depresí. Na léčbu pozitivně reagovalo 71 % žen, které užívaly hormonální substituci, zatímco z těch, které ji neužívalo, reagovalo pozitivně jen 29 %.Výsledky léčby byly tedy statisticky významně lepší u nemocných, které užívaly hormonální substituci. Ukazuje se, že serotonin má synergické účinky s estrogeny. Výsledky této studie jsou dalším argumentem pro zavádění hormonální substituce v menopauze. Estrogeny snižují riziko nejen osteoporózy, kardiovaskulárních chorob a Alzheimerovy nemoci, ale také podstatně zmírňují riziko farmakorezistence při depresích.
Klíčová slova:
deprese - menopauza - SSRI - HRT
Authors:
O. Vinař
Authors‘ workplace:
Psychiatrická léčebna, Praha, ředitel MUDr. Z. Bašný
Published in:
Prakt. Lék. 2001; (5): 283-285
Category:
Overview
A sample of 52 female menopausal depressed patients was divided in to those who were on hormonal substitution (HRT) and those who were not (non HRT). The effects of the treatment with SSRIs were better in the HRT subsample. In 82 % of patients on HRT, remission was achieved during 10 weeks of treatment with the SSRI with which the treatment was started. In comparison, 71 % of patients without HRT had to be switched to another antidepressant to achieve remission. In patients on HRT fewer drug combinations were used and less adverse drug effects were observed.The study shows the beneficial effects of HRT which are important not only for the prevention of osteoporosis, cardiovascular diseases and Alzheimer’s disease. HRT decreases the risk of resistance to SSRI in depresed menopausal women.
Key words:
depression - postmenopausal female patients - SSRI - HRT
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2001 Issue 5
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