Immune Mechanisms in Atherosclerosis
Imunitné mechanizmy v ateroskleróze
Nejasnú etipatogenézu aterosklerózy popisujú v posledných rokoch dve teórie - zápalová a autoimunitná, v ktorých imunitné mechanizmy zohrávajú dôležitú úlohu. Dôkazom ich pôsobenia sú nálezy imunokompetentných buniek, makrofágov a lymfocytov, infiltrujúcich postihnuté cievy vo všetkých štádiách tohto ochorenia. Snahy o využitie týchto mechanizmov v imunomodulácii aterosklerózy sú zatiaľ úspešné len v experimentálnych zvieracích modeloch.
Klíčová slova:
ateroskleróza - imunitné mechanizmy - imunomodulácia.
Authors:
A. Keleová; Š. Nyulassy
Authors‘ workplace:
Združené lekársko-imunologické pracovisko Ústavu preventívnej a klinickej medicíny a FNsP akad. L. Dérera, Bratislava, riaditeľ doc. MUDr. Š. Nyulassy, DrSc.
Published in:
Prakt. Lék. 2001; (5): 260-262
Category:
Overview
The obscure etiopathogenesis of atherosclerosis is described in recent years by two theories - the inflammatory and autoimmune theory where immune mechanisms play an important part. Evidence of its action are findings of immunocompetent cells, macrophages and lymphocytes infiltrating the affected vessels in all stages of the disease. Attempts to make use of these mechanisms in the immunomodulation of atherosclerosis are so far successful only in experimental animal models.
Key words:
atherosclerosis - immune mechanisms - immunomodulation
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
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