Apolipoproteins in Cherokee Children and Adolescents
Apolipoproteiny u dětí a mladistvých Indiánů Cherokee
Vzhledem k k tomu, že američtí Indiáni jsou náchylní k diabetu typu 2 a souvisejícímu kardiovaskulárnímu riziku, stanovili jsme prevalenci rizikových faktorů ve vztahu k věku, takže údaje by mohly odhalit časné prediktory (indicie) a cíle intervence. Studovali jsme Indiány Cherokee staré 5–20 let, kteří jsou členy největšího národa Indiánů v Oklahomě. Při studiu subjektů bez diabetu jsme zjistili, že apolipoprotein B, apoC-III vázaný k apoB a poměr apoB:A-I se zvýšil úměrně k rezistenci na inzulin při půstu (HOMA-IR), kdežto HDL-C, LpA-I a LpA-I:A-II poklesly, zvláště u chlapců během dospívání. Viscerální tuk měřený jako obvod pasu měl významný vliv na HDL lipoproteiny a HDL-C. Lp(a) byl nižší než u jiných etnických skupin, ale pokud byl zvýšen, může to zhoršit kardiovaskulární riziko.
Authors:
P. R. Blackett 1; W. Wang 2; E. Quintana 3; P. Alaupovic 4; E. T. Lee 5
Authors‘ workplace:
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Center for American Indian Health Research, College of Public Health, University of Oklahoma Health
1; Sciences Center, Oklahoma City, Oklahoma
2; WW Hastings Indian Hospital, Tahlequah, Oklahoma
3; Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
Center for American Indian Health Research, College of Public Health, University
4; of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
5
Published in:
Čes-slov Pediat 2006; 61 (9): 477-483.
Category:
Original Papers
Overview
Since American Indians are susceptible to type 2 diabetes and associated cardiovascular risk, we determined the prevalence of risk factors in relation to age so that the data might reveal early predictors and intervention targets. We studied 5–20 year-old Cherokee Indians, who are members of the largest Indian Nation in Oklahoma. When we studied those without diabetes, we found that apolipoprotein B, apoC-III bound to apoB and the apoB:A-I ratio increased in proportion to the fasting insulin resistance (HOMA-IR), whereas HDL-C, LpA-I and LpA-I:A-II decreased, particularly in boys during adolescence. Visceral fat measured as the waist circumference had a significant effect on the HDL lipoproteins and HDL-C. Lp(a) was lower than in other ethnic groups, but when elevated, the levels may compound cardiovascular risk.
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2006 Issue 9
- Diagnosis of Cow Milk Protein Allergy − Current Methods and Their Diagnostic Value
- Subcutaneous vs. Intravenous Immunoglobulins in Patients with CLL
- Inosine pranobex in the treatment of influenza and other respiratory infections of viral etiology
- Inosine Pranobex in the Treatment of Cervical HPV Infections
Most read in this issue
- Primary Disorders of Lipid Metabolism in Children – Our Experience
- Does Artificial Suckling Nutrition Pose a Risk of Atherosclerosis at the Adult Age?
- Food Supplements with Fish Oils – The Composition of Fatty Acids
- National Cholesterol Program in Children’s Population in Slovakia and Its Contribution