The Development of Acute Nonlymphoblastic Leukemia during Treatment of Other Malignanciesin Children
Vznik akútnych nelymfoblastických leukémií v priebehu liečbyiných malignít u detí
Z celkového počtu 273 detí s rôznymi malignitami liečených na Detskom onkologickom oddelení za obdobie 10rokov bol pozorovaný výskyt akútnej nelymfoblastickej leukémie u 4 chlapcov. Leukémia vznikla u 2 detí s akútnoulymfoblastickou leukémiou po 4, resp. 30 mesiacoch trvania kompletnej remisie a u 1 pacienta s non-Hodgkinskýmlymfómom T-typu po 21-mesačnej remisii. ANLL sa zistila aj u dieťaťa s osteosarkómom po 15-mesačnej neúspešnejliečbe. V diskusii k patogenéze sa zvažuje na jednej strane možnosť iniciálnej bilineárnej leukémie a na druhejstrane možný leukemoidný efekt cytostatickej terapie, najmä epipodofylotoxínu, ktorý bol súčasťou liečby u 3 detí.
Klíčová slova:
primárna malignita, sekundárna akútna nelymfoblastická leukémia, karyotypizácia, imunofenotypizácia,epipodofylotoxíny
Authors:
J. Čáp 1; E. Kaiserová 1; G. Kirschnerová 2; O. Babušíková 3
Authors‘ workplace:
Oddelenie detskej onkológie Detskej fakultnej nemocnice s poliklinikou, Bratislava vedúci doc. MUDr. E. Kaiserová, CSc. Oddelenie genetiky nádorov, Národný onkologický ústav, Bratislava vedúci RNDr. V. Zajac, CSc. Oddelenie imunológie nádorov, Ústav exper
Published in:
Čes-slov Pediat 2004; (10): 503-507.
Category:
Overview
Among of the total number of 273 children with different malignancies treated at the Pediatric OncologicDepartment in a period of 10 years in 4 boys secondary nonlymphoblastic leukemia was observed. It occured in2 children with acute lymphoblastic leukemia after 4 and 30 months lasting complete remission and in one childwith non-Hodgkin's lymphoma of T-type after 21 months lasting remission. ANLL was also seen in a patient withosteosarcoma after 15 months of unsuccessful cytostatic, surgical and radiotherapeutic treatment. The possibilityof initial bilinear leukemia on one hand and the possible effect of the cytostatic therapy on the other hand, mainlyof epipodophyllotoxin, which was a part of the chemotherapy in 3 patients, as pathogenic factors of developing ofsecondary myeloid leukemia are discussed.
Key words:
primary malignancy, secondary acute nonlymphoblastic leukemia, karyotyping, immunophenotyping,epipodophyllotoxins
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2004 Issue 10
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