Mixed Form of Acute Child Leukaemia with Hybrid Translocation of the bcr/abl Gene of the Ph Chromosome
Zmiešaná forma detskej akútnej leukémie s hybridnou translokáciou génu bcr/abl Ph chromozómu
Autori predkladajú kazuistiku 11-ročného chlapca so zmiešanou (lymfoidnou a myeloidnou) formou akútnej leukémie. Na začiatku nezrelý typ akútnej lymfoblastickej leukémie sa velmi včasne zmenil na bilineárnu akútnu leukémiu (lymfoblastickú a myeloblastickú) s prítomnostou patologickej hybridnej translokácie génu bcr/abl Ph chromozómu. Intenzívna chemoterapia antracyklínmi, alkylačnými látkami a epipodofylotoxínmi s následnou alogénnou transplantáciou kostnej drene viedli ku kompletnej remisii trvajúcej 7 mesiacov. Následný relaps vznikol z lymfoidnej triedy, remisiu sa nepodarilo dosiahnut.
Klíčová slova:
zmiešaná/bilíniová akútna leukémia, karyotypizácia, imunofenotypizácia, hybridná translokácia bcr/abl Ph chromozómu
Authors:
J. Čáp; E. Kaiserová; G. Kirschnerová; O. Babušíková
Authors‘ workplace:
Oddelenie detskej onkológie Detskej fakultnej nemocnice s poliklinikou, Bratislava Oddelenie genetiky nádorov, Národný onkologický ústav, Bratislava 0ddelenie imunológie nádorov, Ústav experimentálnej onkológie Slovenskej akadémie vied, Bratislava
Published in:
Čes-slov Pediat 2002; (2): 75-78.
Category:
Overview
Authors present the tase-history of an 11-year-old boy with the bilinear (lymphoid and myeloid) form of acute leukaemia. The immature type of acute lymphoblastic leukaemia changes very early in to bilinear acute leukaemia (lymphoid and myeloid) combined with the presence of the pathological hybrid translocation gene bcr/abl Ph Chromosome. Intensive chemotherapy with antracyclines, alkylating agents and epipodophyllotoxins followed by allogeneic bone marrow transplantation led to complete remission lasting 7 months, but did not prevent fatal outcome of the disease.
Key words:
mixed/biclonal acute leukaemia, karyotyping, immunophenotyping, hybrid translocation gene bcr/abl Ph Chromosome
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2002 Issue 2
- Diagnosis of Cow Milk Protein Allergy − Current Methods and Their Diagnostic Value
- Subcutaneous vs. Intravenous Immunoglobulins in Patients with CLL
- Inosine pranobex in the treatment of influenza and other respiratory infections of viral etiology
- Inosine Pranobex in the Treatment of Cervical HPV Infections
Most read in this issue
- New Method of Assessment of Bone Age „TW3" and First Results of its Application in the Czech Republic
- Helicobacter Heihnannii Infection with Primary Gastric Ulcer and its Role in the Development of Diseases of the Gastroduodenal Region in Children
- Salmonella Osteomyelitis in Children from the Aspect of the Orthopaedist
- Possible Conservative Procedure in the Treatment of Infants with Low Risk Neuroblastome