Antibodies against PRP Antigen of Haemophilus influenzae Type b (anti PRP Hib) in PairedSera of Mothers and Neonates
Protilátky proti PRP antigénu Haemophilus influenzae typ b(anti PRP Hib) v párových sérach matky a novorodenca
Počas 4 rokov trvania surveillance hemofilových infekcií v Slovenskej republike sa 7 % všetkých prípadovinvazívnych ochorení vyskytlo u detí mladších ako 3 mesiace. Bolo vyšetrených 650 párových vzoriek matka-no-vorodenec s cieľom zistiť hladinu anti PRP Hib protilátok.Priemerná hladina anti PRP protilátok bola 3,16 mg/l u matiek a 2,87 mg/l u novorodencov. Pomer prenosuprotilátok u individuálnych párových sér bol 17 - 98 % (priemer 91,7 %). 15 % novorodencov malo hladinu antiPRP Hib protilátok nižšiu ako 0,5 mg/l.Autori zistili, že 15 % novorodencov nebude mať vo veku 3. mesiaca života protektívnu hladinu anti PRP Hibprotilátok vďaka nízkym hladinám u matky, alebo vďaka nedostatočnému prenosu protilátok od matky.
Klíčová slova:
Haemaphilus influenzae typ b, protilátky, matka-novorodenec
Authors:
J. Gajdoš; E. Nováková 1; K. Tancárová
Authors‘ workplace:
Detské oddelenie NsP, Levoča
Published in:
Čes-slov Pediat 2000; (7): 448-451.
Category:
Overview
During a four-year surveillance of haemophilus infections in the Slovak Republic 7% of all cases of invasivecases in children occurred in children under the age of 3 months. 650 paired mother-neonate samples wereexamined with the objective to assess the anti PRP Hib antibody level.The mean level of PRP antibodies was 3.16 mg/l in mothers and 2.87 mg/l in neonates. The ratio of transmissionof antibodies in individual paired sera was 17 - 98% (mean 91.7 %). 15 % of the neonate s had a level of anti PRPHib antibodies lower than 0.5 mg/l.The authors found that 15 % neonates do not have at the age of 3 months a protective level of anti PRB Hibantibodies either due to low levels in the mother or due to inadequate transmission of antibodies from the mother.
Key words:
Haemophilus influenzae type b, antibodies, mother - neonates
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2000 Issue 7
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