Interleukin-1 receptor antagonist (IL-1RA) genepolymorphism in patients with ankylosing spondylitis
Polymorfismus v genu pro antagonistu receptoru IL-1 (IL-1RA) u pacientů s ankylozující spondylitidou
Úvod.
Jen malá část HLA B27 pozitivních jedinců onemocní ankylozující spondylitidou (AS). Vnímavostk AS je nejspíše určena interakcí několika genů a nejlépe odpovídá oligogennímuepistatickémumodelu. Cíl. Cílem studie bylo zjistit, jaká je role genu kodujícího antagonistu receptoru intreleukinu-1 (IL-1RN) ve vnímavosti k AS. Metody. Byl vyšetřen soubor 215 nemocných s AS a některýchčlenů jejich rodin a kontrolní soubor 170 zdravých dárců krve. Charakteristika nemocných bylaprovedena za pomoci dotazníků podle systému Bath. Alely IL-1RN byly detekovány pomocí PCR.Výsledky. Frekvence alely IL-1RN*2 (24,7 % vs. 15,0 %; p
Klíčová slova:
ankylozující spondylitida, polymorfismus genu IL-1RN, alela IL-1RN*2
Authors:
J. Hrba; Š. Růžičková; J. Vencovský
Authors‘ workplace:
Revmatologický ústav, Praha
Published in:
Čes. Revmatol., , 2004, No. 2, p. 55-60.
Category:
Overview
Introduction.
Ankylosing spondylitis (AS) affects only a minor portion of HLA B27+ individuals.Susceptibility to AS is determined by interactions of several genes and answers best to an oligogenicepistatic model. Aim. The aim was to find out if the gene encoding for IL-1 receptor antagonist(IL-1RN) has a role in the susceptibility to AS. Methods. Two hundred and fifteen patients with AS,as well as members of 38 families, were investigated and compared with 170 healthy controls.Patients were characterized by using the Bath system. Alleles of IL-1RN gene were detected by PCR.Results. IL-1RN*2 allele frequency (24.7% vs. 15.0%; p
Key words:
ankylosing spondylitis, polymorphism of IL-1RN gene, IL-1RN*2 allele
Labels
Dermatology & STDs Paediatric rheumatology RheumatologyArticle was published in
Czech Rheumatology
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