Effect of Humectants on Pharmaceutical Availability and Rheological Properties of Cetirizine-Containing Hydrogels
Vplyv humektantov na farmaceutickú dostupnosť a reologické vlastnosti hydrogélov s cetirizí
Práca je zameraná na formuláciu antihistaminika – cetirizínu do hydrogélov. Na prípravu hydrogélov boli použité deriváty celulózy – hydroxyetylcelulóza (HEC) a metylcelulóza (MC). Pretože nevyhnutnou súčasťou hydrogélov sú pomocné látky zo skupiny humektantov, v príspevku sa sleduje ich vplyv (glycerolu – GL, propylénglykolu – PG a sorbitolu – SO) na reologické vlastnosti a farmaceutickú dostupnosť cetirizínu pri jeho formulácii do hydrogélu. Z dosiahnutých výsledkov štúdie vyplýva, že z hľadiska dermálnej aplikácie sú pre cetirizín v tomto štádiu výskumu optimálne hydrogély následovného zloženia: 3% HEC + 15% GL a 2,5% MC + 10% SO.
Kľúčové slová:
hydrogély – cetirizín – hydroxyetylcelulóza – metylcelulóza – humektanty
Authors:
Z. Capková; Z. Vitková; S. Uhrovská
Authors‘ workplace:
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie, SR
Published in:
Čes. slov. Farm., 2005; 54, 226-230
Category:
Original Articles
Overview
The paper is concerned with the formulation of the antihistamine cetirizine into hydrogels. The cellulose derivatives hydroxyethylcellulose (HEC) and methylcellulose (MC) were employed to prepare hydrogels. As auxiliary substances from the group of humectants are indispensable components of hydrogels, the paper examines their effect (glycerol – GL, propylene glycol – PG, and sorbitol – SO) on the rheological properties and pharmaceutical availability of cetirizine in its formulation into hyrogel. The obtained results show that from the viewpoint of dermal administration for cetirizine at this stage of research hydrogels of the following composition are optimal: 3 %HEC + 15% GL and 2.5% MC + 10% SO.
Key words:
hydrogels – cetirizine hydroxyethylcellulose – methylcellulose – humectants
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2005 Issue 5
- FDA Warns Against Self-Monitoring Glucose Using Smartwatches. What About in Czechia?
- What is the future of xenotransplantation? Pig liver and kidneys transplanted to humans for the first time
- Vitamins in Prevention and Treatment of COVID-19
Most read in this issue
- The Development of the Composition of Castellan’s Solution
- Ouabain: from an Arrow Poison to a New Steroidal Hormone
- Blockers of β-Adrenergic Receptors – a Group of Chiral Agents Stereoselective Synthesis of β-Blockers
- Dimethindene Determination in Various Dosage Forms by Means of Capillary Isotachophoresis