Dimethindene Determination in Various Dosage Forms by Means of Capillary Isotachophoresis
Stanovenie dimetindenu v rôznych liekových formách kapilárnou izotachoforézou
Kapilárna izotachoforéza bola využitá na stanovenie dimetindenu v rôznych liekových formách. Bolo preskúšaných niekoľko elektrolytových systémov s rôznym zložením a rôznym pH. Pre validáciu metódy a stanovenie dimetindenu v reálnych vzorkách (gél, kvapky, kapsule) boli vybrané dva elektrolytové systémy. Bola hodnotená presnosť, správnosť, linearita, robustnosť a selektivita ITP metódy pre obidva elektrolytové systémy. Predúprava vzorky pred analýzou spočívala v rozpustení a nariedení príslušnej liekovej formy s obsahom dimetindenu demineralizovanou vodou na požadovanú koncentráciu. Takto upravená vzorka bola priamo dávkovaná do prístroja.
Kľúčové slová:
kapilárna izotachoforéza – kapilárna elektroforéza – dimetinden – liek – validácia
Authors:
P. Kubačák; P. Mikuš; I. Valášková; Emil Havránek
Authors‘ workplace:
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmaceutickej analýzy a nukleárnej farmácie, SR
Published in:
Čes. slov. Farm., 2005; 54, 231-234
Category:
Original Articles
Overview
Capillary isotachophoresis was employed to determine dimethindene in various dosage forms. Several electrolyte systems of varying compositions and varying pH were tested. For validation of the method and the determination of dimethindene in real samples (gel, drops, capsules), two electrolyte systems were selected. Precision, correctness, linearity, robustness, and selectivity of the ITP method were evaluated for both electrolyte systems. The pre-treatment of the sample prior to analysis consisted in dissolving and diluting the pertinent dosage form containing dimethindene with demineralized water to the required concentration. The sample adjusted in this way was directly dosed into the apparatus.
Key words:
capillary isotachophoresis – capillary electrophoresis – dimethindene – pharmaceutical product – validation
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
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