Nitric oxide: its metabolism and importance for an organism
Oxid dusnatý – jeho metabolismus a význam pro organismus
Oxid dusnatý je produkován různými formami nitroxidsyntázy (NOS). V organismu plní řadu fyziologických funkcí – signální, uplatňuje se přivazodilataci, v imunitních reakcích, inhibuje agregaci trombocytů aj. Se superoxidem tvoří peroxynitrit, který poškozuje nitrací zvláště bílkoviny.Z klinického hlediska se oxid dusnatý uplatňuje v ARDS, septického šoku, ischemie, diabetu, u zánětlivých stavů, revmatické artritidy aj. Využívá sei v inhalační terapii.
Klíčová slova:
oxid dusnatý – nitroxidsyntáza – vazodilatace – ARDS – inhalace oxidu dusnatého
Authors:
J. Racek; I. Novák 1; V. Holeček; V. Šrámek 1
Authors‘ workplace:
Ústav klinické biochemie a laboratorní diagnostiky1 I. interní klinika LF UK a Fakultní nemocnice v Plzni
Published in:
Anest. intenziv. Med., , 1999, č. 4, s. 169-173
Category:
Overview
Nitric oxide is produced by various forms of nitric oxide synthases (NOS). Nitric oxide exerts various physiologic functions; NO producesvasodilation, inhibits thrombocytes aggregation, effects immune response and serves as a signal messenger. Nitric oxide with superoxide generatesperoxynitrite which destructs proteins by nitration. Nitric oxide can be applied in ARDS, septic shock, ischemic conditions, diabetes, inflammatoryconditions, rheumatoid arthritis and other clinical settings. It is used also in inhalational therapy.
Key words:
nitric oxide – nitric oxide synthase – ARDS – nitric oxide inhalation
Labels
Anaesthesiology, Resuscitation and Inten Intensive Care MedicineArticle was published in
Anaesthesiology and Intensive Care Medicine
1999 Issue 4
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