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Immunomodulation and Romiplostim − What Does the Recently Published iROM Study Say?
Primary immune thrombocytopenia (ITP) is caused by an immunity disorder, involving not only the production of antibodies but also changes in cytokine levels, predominance of Th1 lymphocytes over Th2, increase in Th17 cells, and conversely a decrease in T-regulatory lymphocytes (Tregs). One treatment option is the use of thrombopoietin receptor agonists (TPO-RA), which primarily increase platelet production. Recently, attention has also been focused on their potential immunomodulatory effects and protolerogenic effect associated with Tregs…
ICIS Report: Potential of TPO-RA as Early Immunomodulatory Treatment of Immune Thrombocytopenia
The report from the meeting of the Intercontinental Cooperative ITP Study Group (ICIS) in 2022 in…
Impact of Azacitidine Maintenance Therapy on Survival of Patients with AML in Remission Depending on Initial Chemotherapy
The QUAZAR AML-001 study showed that oral azacitidine maintenance therapy significantly prolongs…
Doc. Milan Sova: AAT substitution is available to all indicated patients. It is therefore crucial to now educate about the necessity of regular treatment
Alpha-1-antitrypsin deficiency (AATD) is one of the most common genetic disorders in adults. It is…
Anabolic Antiosteoporotic Treatment as a First Step in Patients with Very High Fracture Risk
According to the 2022 opinion of the ESCEO (European Society for Clinical and Economic Aspects of…
Cardio-renal-metabolic syndrome in context
The increase in the incidence of type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and...
MUDr. Petra Garnolová: The combination of medical cannabis with other analgesics is the ideal way to achieve the best effect with the fewest side effects
Medical cannabis is gradually finding its way to many patients with various ailments, including…
Calculator Naxiva - Application for Easy Prescription of Medical Cannabis Extracts
The new Calculator Naxiva application, specifically designed for doctors prescribing medical…
A Decade of Therapy Targeting B Lymphocytes in MS
Ocrelizumab is not only a pioneer but also a highly effective and still promising modality for the treatment...
Diagnosis and Management of Interstitial Lung Processes Associated with Rheumatoid Arthritis
Interstitial lung processes (ILD) are common yet insufficiently diagnosed complications of…