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Schizofrenie_ataka_žena

Adverse effects of antipsychotics in the treatment of schizophrenia negatively affect cognitive functions

18. 5. 2021 Source: Modern Treatment of Schizophrenia

Schizophrenia is a severe psychiatric disorder characterized by a wide range of symptoms, with cognitive dysfunctions being one of its domains. Antipsychotics (APs) are used for treatment, but their effectiveness in improving cognitive functions is unclear, and they can simultaneously worsen cognition through their adverse metabolic effects, leading to a reduced lifespan for patients with schizophrenia.

Arteriální_plicní_hypertenze_PAH

Systemic Manifestations of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by remodeling of the pulmonary vessels, leading to the development of right-sided heart failure. Aside from the…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
Bezpečnost_léky_farmakovigilance

Safety of Riociguat in the Treatment of Thromboembolic Pulmonary Hypertension in Common Practice

In March 2021, the final safety results of riociguat in the treatment of thromboembolic pulmonary arterial hypertension in real-world practice were published from the international EXPERT registry,…
16. 5. 2021 Source: Pulmonary hypertension (CTEPH, PAH)
PL_astma_inhalator_zena_kasel

Alpha-1-Antitrypsin Deficiency and Its Association with Atopy in Asthmatics

Literature mentions the coincidence of asthma and alpha-1-antitrypsin deficiency, which is caused by a mutation in the SERPINA1 gene. The aim of the study presented below was to determine whether the…
14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
pacient_lekarka_covid_rouska_maska

Antiviral and Anti-inflammatory Effects of Alpha-1-Antitrypsin in the Treatment of COVID-19

Human alpha-1-antitrypsin (AAT) is a circulating blood glycoprotein that has been used for decades in the treatment of patients with AAT deficiency, lung damage, and emphysema, helping to prevent…
14. 5. 2021 Source: Deficiency of Alpha-1-Antitrypsin
Laboratoř_měření_jaterní_hodnoty_ALP_test

To what extent can the actual level of ALP, ALT, or bilirubin differ from the measured value?

A physician who bases clinical decisions on laboratory-determined values of biological parameters or their changes should always consider the possible measurement deviation, which for alkaline…
14. 5. 2021 Source: Primary Biliary Cholangitis
Parkinsonova choroba_žena_asistentka_chodítko

Treatment of Motor Symptoms of Parkinson's Disease

Parkinson's disease (PD) is one of the few neurodegenerative disorders for which effective symptomatic treatment is available. Unfortunately, causal or even neuroprotective therapy with proven…
12. 5. 2021 Source: Parkinson's Disease
medicína žena břicho bolest žaludek stomie

Liposomal Pegylated Irinotecan in the Treatment of Pancreatic Tumors

Combined treatment with liposomal pegylated irinotecan, 5-fluorouracil (5-FU), and leucovorin (LV) significantly improves overall survival in patients with metastatic ductal carcinoma of the…
11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas
PL_pankreas_rakovina

New Treatment Option for Metastatic Pancreatic Cancer –⁠ Pegylated Liposomal Irinotecan

The 2019 review article is dedicated to the use of nanoliposomal irinotecan, its toxicity, and its potential use in the treatment sequence of metastatic pancreatic ductal adenocarcinoma.
11. 5. 2021 Source: Treatment of Gastrointestinal Carcinomas
faktor VIII hemofilie krev zkumavka

What FVIII Levels Are Ideal for Preventing Bleeding in Hemophilia A?

Recent studies indicate that target trough levels of factor 1–3% during prophylactic treatment are insufficient to fully prevent clinical and subclinical bleeding. With a sustained FVIII level > 15%,...
10. 5. 2021 Source: Hemophilia
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