The variable histogenesis and biology of selected bland fibroblastic lesions of the breast – pitfalls in the differential diagnostics and optimal therapeutic approach (three case reports)
Authors:
Z. Kinkor
Authors‘ workplace:
Šiklův ústav patologie, LF UK a FN Plzeň
; Bioptická laboratoř s. r. o., Plzeň
Published in:
Rozhl. Chir., 2024, roč. 103, č. 7, s. 275-280.
Category:
Case Report
doi:
https://doi.org/10.48095/ccrvch2024275
Overview
Presented are three casuistics of seemingly identical breast lesions which even by adopting advanced laboratory techniques may represent diagnostic challenge. Microscopic features of some bland spindle cell lesions of different histogenesis (epithelial or mesenchymal) are misleading and a potential source of unaware errors, which might affect optimal therapeutic strategy. In the setting of three diverse entities (low-grade spindle cell metaplastic carcinoma, desmoid fibromatosis and phyllodes tumor) is documented both demanding diagnostic algorithm and revealing molecular landscape on one side as well as evolving predictive/prognostic parameters on the other one. Close interdisciplinary cooperation is inevitable for accurate interpretation/understanding of revealed diagnostic facts which is required for adjustment of competent rational and individualized therapy.
Keywords:
breast – phyllodes tumor – desmoid fibromatosis – low-grade fibromatosis-like metaplastic carcinoma – beta-catenin
Sources
- Sneige N, Yaziji H, Mandavilli SR et al. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol 2001; 25(8): 1009–1016. doi: 10.1097/00000478-200108000-00004.
- Pham KH, Nguyen CV, Do TA et al. Fibromatosis-like metaplastic carcinoma: a triple negative breast cancer with clinically indolent behavior. Case Rep Oncol 2022; 15(3): 816–826. doi: 10.1159/000526535.
- Scheer L, Lodi M, Moliere S et al. Medical treatment of mammary desmoid-type fibromatosis: which benefit? World J Surg Oncol 2017; 15(1): 86. doi: 10.1186/s12957017-1148-x.
- Le Guellec S, Soubeyran I, Rochaix P et al. CTNNB1 mutation analysis is a useful tool for the diagnosis of desmoid tumors: a study of 260 desmoid tumors and 191 potential morphologic mimics. Mod Pathol 2012; 25(12): 1551–1558. doi: 10.1038/modpathol.2012.115.
- Norkowski E, Masliah-Planchon J, Le Guellec S et al. Lower rate of CTNNB1 mutations and higher rate of APC mutations in desmoid fibromatosis of the breast: a series of 134 tumors. Am J Surg Pathol 2020; 44(9): 1266–1273. doi: 10/1097PAS.0000000000001517.
- Meyer B, Stirzaker C, Ramkomuth S et al. Detailed DNA methylation characterization of phyllodes tumours identifies a signature of malignancy and distinguishes phyllodes from metaplastic breast carcinoma. J Pathol 2024; 262(4): 480–494. doi: 10.1002/path.6250.
doc. MUDr. Zdeněk Kinkor, Ph.D.
Bioptická laboratoř s.r.o.
Mikulášské náměstí 4
326 00 Plzeň
kinkor@biopticka.cz
Labels
Surgery Orthopaedics Trauma surgeryArticle was published in
Perspectives in Surgery
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