The Antiphospholipid Syndrome and Antiphospholipid Antibodies
ANTIFOSFOLIPIDOVÝ SYNDROM A ANTIFOSFOLIPIDOVÉPROTILÁTKY
Antifosfolipidový syndrom je vzácné systémové autoimunitní onemocnění, charakterizované opakovanými tepen-ními a žilními trombózami, recidivujícími spontánními potraty, a trombocytopenií. Laboratorně je definován pří-tomností protilátek proti fosfolipidům. Tyto protilátky jsou prokazovány funkčními testy lupusového antikoagulans,antikardiolipinovými ELISA testy, ELISA testy prokazujícími protilátky proti b2-glykoproteinu 1 a proti jinýmkofaktorům a fosfolipidům. Patogenetické mechanizmy vzniku trombóz nejsou zatím uspokojivě vysvětleny. Dia-gnostické testy a metody detekce antifosfolipidových protilátek nejsou dosud dostatečně standardizovány.
Klíčová slova:
antifosfolipidový syndrom, antifosfolipidové protilátky, lupus antikoagulans, laboratorní dia-gnostika.
Authors:
K. Malíčková; T. Fučíková
Authors‘ workplace:
Ústav klinické imunologie a alergologie 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 2001; : 465-468
Category:
Overview
Antiphospholipid syndrome is a rate systemic autoimmune disease characterized by widespread arterial and venousthrombosis, recurrent abortion and thrombocytopenia. Laboratory tests reveal antibodies against phospholipids.These antibodies are detected by functional tests for the lupus anticoagulant, the anticardiolipin ELISA, theanti-b2-glycoprotein 1 ELISA and ELISA tests for antibodies against other cofactors and phospholipids. Pathogeneticmechanisms of thrombosis are poorly understood. Diagnostic assays for detection of antiphospholipid have not beenyet adequately standardized.
Key words:
antiphospholipid syndrome, antiphospholipid antibodies, lupus anticoagulant, laboratory detection.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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