Oral antidiabetic drugs in treatment of type 1 diabetes mellitus

Czech version

Authors: Ludmila Brunerová ¹; Jan Brož ²
Authors‘ workplace: Diabetologické centrum II. interní kliniky 3. LF UK a FN Královské Vinohrady, Praha ¹; Interní klinika 2. LF UK a FN v Motole, Praha ²
Published in: Vnitř Lék 2016; 62(12): 998-1003
Category: Reviews

Overview

Review article summarizes current knowledge of the use of oral antidiabetics (approved for treatment of type 2 diabetes) in type 1 diabetic patients. Following drugs were tested: metformin, gliptines, analogues of GLP-1, glitazones, inhibitors of α-glukozidase and gliflozines. The latter seem to be the most perspective ones, however, more studies are warranted for definitive confirmation of their efficacy and safety. Current evidence-based results did not clearly show efficacy and safety of oral antidiabetics as adjuvant treatment in type 1 diabetic patients and thus, they still represent off-label treatment in this type of diabetes.

Key words:
oral antidiabetics – type 1 diabetes mellitus

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