Non-pharmacological treatment – results from Poděbrady

Czech version

Authors: Lukáš Zlatohlávek ¹; Michal Vrablík ¹; Zuzana Urbanová ²; Hana Pejšová ¹; Jaroslav Hubáček ³; Richard; Češka ¹
Authors‘ workplace: III. interní klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA ¹; Klinika dětského a dorostového lékařství 1. LF UK a VFN Praha, přednosta prof. MUDr. Jiří Zeman, DrSc. ²; Laboratoř molekulární genetiky IKEM Praha, přednosta MUDr. Jan Piťha, CSc. ³
Published in: Vnitř Lék 2014; 60(11): 958-962
Category: Reviews

Overview

Objectives:
The study was aimed to determine risk factors of atherosclerosis after one month lifestyle intervention in overweight/obese children and also FTO and MC4R gene variants associated with obesity.

Design and Methods:
350 non-diabetic Czech children (age 13.7 ± 2.1 years, 163 ± 10.6 cm hight) was examined. Before and after 4 weeks of lifestyle intervention (comprising a reduction of energy intake), biochemical and anthropometrical measurements were performed.

Results:
The mean weight loss achieved was 6.2 ± 2.1 kg (P < 0.001). Significant associations between BMI decrease and FTO and MC4R variants were found. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight in comparison to the non-carriers (P < 0.0009 for BMI and P < 0.002 for body weight). The differences remain significant after adjustment for sex age and baseline values (P = 0.004 for BMI and P = 0.01 for body weight).

Conclusions:
It is necessary to look for the risk individuals with wrong response to the regime intervention. This individuals is necessary early treat with drugs to prevention clinically complications.

Key words:
childhood obesity – components of metabolic syndrome – predisposition – response to intervention

Sources

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