Survey of AntimicrosporidialAntibodies in Patients with Secondary Immunodeficiency
Sledovanie výskytu antimikrosporídiových protilátoku pacientov so sekundárnou imunodeficienciou
Mikrosporídie sú obligátne intracelulárne parazity eukaryotického typu infikujúce množstvo bezstavovcovaj stavovcov, vrátane človeka. V humánnej populácii majú charakter oportúnnych mikroorganizmov,najmä u pacientov s rôznym stupňom imunodeficiencie. Na prítomnosť špecifickýchanti-mikrosporídiových (anti-Encephalitozoon intestinalis) protilátok bolo vyšetrených sérologickoumetódou ELISA 318 krvných sér ľudí rozdelených do 2 skupín. Prvú skupinu tvorilo 120pacientov so sekundárnou imunodeficienciou, v druhej skupine bolo na porovnanie vyšetrených198 imunokompetentných ľudí. Špecifické anti-E. intestinalis protilátky boli zistené u 29 zo 120pacientov so sekundárnou imunodeficienciou (24,16 %), a u 20 zo 198 imunokompetentných ľudí(10,1 %).
Klíčová slova:
mikrosporídie – Encephalitozoon intestinalis – imunodeficiencia – protilátky – ELISA.
Authors:
M. Halánová 1; L. Čisláková 1; J. Adam 2; A. Valenčáková 3; P. Bálent 3
Authors‘ workplace:
Ústav epidemiológie, Lekárska fakulta UPJŠ, Košice 2II. gynekologicko-pôrodnícka klinika, Lekárska fakulta UPJŠ, Košice 3Univerzita veterinárskeho lekárstva, Košice
1
Published in:
Epidemiol. Mikrobiol. Imunol. , 2004, č. 2, s. 78-80
Category:
Overview
Microsporidia are a group of eukaryotic obligate intracellular parasites that infect most invertebratesand all classes of vertebrates, including man. In human population, microsporidia are emergingas opportunistic pathogens in immunocompromised patients. Two groups of human sera (318serum samples) were tested by ELISA for the presence of specific antimicrosporidial (anti-Encephalitozoonintestinalis) antibodies. Group 1 included 120 patients with secondary immunodeficiency,group 2 consisted of 198 immunocompetent controls. Anti-Encephalitozoon intestinalis antibodieswere detected in 29 (24.16 %) patients and 20 (10.1 %) immunocompetent controls. Thedifference in prevalence of antibodies against Encephalitozoon intestinalis between the groups wasstatistically significant (P
Key words:
microsporidia – Encephalitozoon intestinalis – immunodeficiency – antibodies – ELISA.
Labels
Hygiene and epidemiology Medical virology Clinical microbiologyArticle was published in
Epidemiology, Microbiology, Immunology
2004 Issue 2
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