Calcific Aortic Stenosis – Inflammatory Disease
Authors:
Ivo Šteiner
Authors‘ workplace:
Fingerlandův ústav patologie LF UK a FN, Hradec Králové
Published in:
Čes.-slov. Patol., 60, 2024, No. 2, p. 124-128
Category:
Original Article
Overview
In developed countries, calcific aortic stenosis (CAS) has become the most common acquired valvular disease and cause for valve replacement. The prevalence of the disease increases with age, reaching over 5 % in adults over 75 years of age. The cases of CAS are classified as either of a previously normal (tricuspid) aortic valve (senile, syn. age – related, “sclerotic” type), or based on a congenitally malformed, usually bicuspid aortic valve.
This paper is a brief summary of our 5 previous publications from the years 2007 – 2021, devoted to histopathology of CAS, namely to vascularization, inflammatory infiltrate and metaplastic ossification of the valve, and also to topography of these lesions in individual valve cusps.
We conclude that calcification of the aortic valve is not a passive degenerative lesion, but an active multifactorial inflammatory process driven by cells native to the aortic valve. Pathogenesis of CAS is similar to that of atherosclerosis.
Keywords:
Pathogenesis – Aortic valve – inflammation – calcific aortic stenosis
Sources
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Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2024 Issue 2
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