Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT). Report of Case Suggesting Neoplastic Origin of Intratumoral Myoid Cells
Tzv. „uterine tumor resembling ovarian sex cord tumor“ (UTROSCT). Popis prípadu s nálezom podporujúcim neoplastický pôvod intratumorálnych myoidných buniek
Popisujeme prípad UTROSCT-u, ktorý bol zaujímavý z hľadiska histogenézy myoidných buniek (tieto bunky sú často v týchto tumoroch prítomné medzi typickými „sex cord-like” štruktúrami). Doposiaľ je diskutované, či ide o bunky neoplastické alebo len o nenádorové bunky preexistujúceho myometria. V prezentovanom prípade bola imunohistochemicky zreteľná v sex cord bunkách aj myoidná diferenciácia (okrem epitelovej a sex-cord diferenciácie). Na druhej strane, ojedinelé myoidné bunky exprimovali sex cord marker calretinín. Toto fenotypické prekrývanie favorizuje nádorový pôvod myoidných buniek a rozširuje spektrum možných diferenciácií v UTROSCT-e. Ďalším imunohistochemickým nálezom bola pozitivita cytokeratínu a stromálneho markeru CD10 v sex-cord aj myoidných bunkách. Pozorovanie komplexného fenotypu ďalej podporuje nedávne výsledky Irvinga a spol., ktorý označili UTROSCT za polyfenotypický nádor s „pravou“ sex cord diferenciáciou.
Kľúčové slová:
maternica - UTROSCT – myoidná diferenciácia - CD10 – inhibín
Authors:
M. Zámečník 1; M. Staník 2
Authors‘ workplace:
Šikl’s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic
1; Department of Pathology, General Hospital, Trenčín, Slovak Republic
2
Published in:
Čes.-slov. Patol., 42, 2006, No. 3, p. 145-149
Category:
Overview
We report a case of double uterine tumor resembling ovarian sex cord tumor (UTROSCT). The tumor was composed of sex cord-like cords, nests and tubules, and bundles of myoid cells. The lesion was interesting especially in regard to histogenesis of intratumoral myoid cells. It is not known whether these cells are neoplastic or whether they represent preexisting myometrial smooth muscle cells entrapped into the tumor. In the present case, the sex cord-like epithelioid cells showed immunohistochemically myoid features in addition to features of epithelial, sex cord and endometrial stromal differentiation. The spindle cells expressed myoid, epithelial and endometrial stromal markers, but some of them were positive for sex cord marker calretinin. This immunophenotypic overlap between sex cord-like and myoid spindle elements indicates that the spindle cells of UTROSCT represent divergent line of differentiation of neoplastic cell rather than entrapped myometrial cells. It further expands the spectrum of possible differentiations in this polyphenotypic neoplasm.
Key words:
uterine tumor resembling ovarian sex cord tumor – UTROSCT - immunohistochemical examination – smooth muscle differentiation - CD10
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2006 Issue 3
Most read in this issue
- Sessile Serrated Adenomas of the Large Bowel. Clinicopathologic and Immunohistochemical Study Including Comparison with Common Hyperplastic Polyps and Adenomas
- Low Grade Myofibroblastic Sarcoma of Tongue: a Case Report
- Leiomyoma of the Gastrointestinal Tract with Intracytoplasmic Inclusion Bodies Report of Three Cases
- The Use of Immunohistochemistry in the Differential Diagnosis of Thyroid Gland Tumors with Follicular Growth Pattern