Adenoid Basal Epithelioma of the Uterine Cervix in 21-Year-Old Patient. Report of a Case with Histologic and Immunohistochemical Study
Adenoidne bazaloidný epitelióm cervixu u 21-ročnej pacientky. Popis prípadu s histologickým a imunohistochemickým nálezom
Popisujeme prípad adenoidne bazaloidného epiteliómu (ABE) cervixu u 21-ročnej pacientky. ABE sa vyskytuje typicky v postmenopauze a v našom prípade ide o doposiaľ najmladšiu pacientku s týmto tumorom. Tumor bol asociovaný s CIN3. Histologický obraz bol typický, navyše boli u ojedinelých glandulárnych buniek zreteľné štruktúry podobné cíliam tubálneho typu.
Imunohistochemicky bola zreteľná pozitivita p63, CD10, estrogénových a progesterónových receptorov, p16 a bcl-2. CEA bol negatívny. Imunohistochemický nález svedčí spolu s morfológiou pre tuboendometrioidnú diferenciáciu v tumore pochádzajúcom z rezervných buniek. Nález koilocytických zmien a expresia p16 potvrdzujú predpokladanú úlohu vírusu HPV v onkogenéze tohto tumoru.
Kľúčové slová:
adenoidne bazaloidný karcinóm – CIN – CD10 – tuboendometrioidná diferenciácia – krček maternice
Authors:
M. Zámečník 1; A. Skřivánek 2
Authors‘ workplace:
Šikl’s Department of Pathology, Medical Faculty Hospital
Charles University, Pilsen, Czech Republic
1; Private Gynecologic Surgery, Olomouc, Czech Republic
2
Published in:
Čes.-slov. Patol., 41, 2005, No. 4, p. 157-162
Category:
Original Article
Overview
A case of adenoid basal epithelioma (ABE) of the uterine cervix in 21-year-old woman is reported. The patient’s age appears to be lowest among cases of ABE reported to date. The tumor showed typical histologic features of ABE and was associated with CIN3. In addition, rare tumor cells had surface cilia-appearing structures suggesting tubal differentiation. Immunohistochemically, the tumor was reactive for p63, CD10, ER, PR, p16 and bcl-2, and negative for CEA. Thus, the immunophenotype also suggests possible partial tuboendometrioid differentiation in the glandular component of the lesion. It further indicates, along with finding of associated CIN, a role of oncogenic HPV in pathogenesis of ABE.
Key words:
adenoid basal epithelioma – CIN – CD10 – tuboendometrioid differentiation – uterine cervix
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2005 Issue 4
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