Atypical Oxyphilic Metaplasia of the Uterine

České info

Atypická oxyfilná metaplázia krčku maternice

Atypická oxyfilná metaplázia (AOM) krčku maternice je novšie popísaná benígna lézia, ktorámôže histologicky napodobňovať prekanceróznu alebo malígnu glandulárnu atypiu. Demonštro-vaný je nález tejto lézie u 37-ročnej ženy. Bunky AOM mali pleomorfné hyperchrómne jadrá bezmitóz a svetlú až oxyfilnú cytoplazmu. Diferenciálne diagnosticky bolo potrebné odlíšiť AOM odadenokarcinómu „in situ“, adenoma malignum, Arias-Stella reakcie krčku maternice, zápaloveja postradiačnej atypie. V niektorých endocervikálnych žliazkach boli zreteľné prechody medziAOM a tubárnou metapláziou. Podobné oxyfilné a tubárne zmeny sa našli aj v korporálnom endo-metriu, čo môže svedčať pre patogenetickú príbuznosť oxyfilných a tubárnych zmien krčku i kor-porálneho endometria.

Klíčová slova:
oxyfilná metaplázia - endocervikálna atypia

Authors: M. Zámečník ^1,2
Authors‘ workplace: Department of Pathology, Postgraduate Medical School, Bratislava, Slovak Republic ¹
Published in: Čes.-slov. Patol., , 2000, No. 2, p. 60-64
Category:

Overview

A new example of atypical oxyphilic metaplasia (AOM) of the uterine endocervix occurring ina 37-year-old female is presented. This rare lesion is worrisome in appearance but entirely indo-lent and needs to be distinguished from glandular atypia or adenocarcinoma in situ of the cervix.In the present case, there were seen transitions between AOM and tubal metaplasia in somecervical glands. Additionally, similar eosinophilic and ciliated changes were found in the endo-metrium. These findings suggest that AOM, tubal metaplasia of the cervix and eosinophilic meta-plasia of the endometrium may be related from the pathogenetic viewpoint.

Key words:
oxyphilic metaplasia - endocervical atypia

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Article was published in

Czecho-Slovak Pathology

2000 Issue 2