Changes of Leptin in Chronically Sick Children
Zmeny leptínu u chronicky chorých detí
Leptín je proteínový hormón tvoriaci sa prevažne v adipocytoch, ktorý sa z organizmu vylučuje obličkami.Hypoleptinémia je spojená so znížením percenta telesného tuku a pozoruje sa pri malnutrícii a vytrvalostnomšporte. Hyperleptinémia je prítomná u pacientov s chronickou renálnou insuficienciou a u obéznych jedincov.Autori vyšetrili v súbore 80 detí (pacienti s chronickou renálnou insuficienciou, malnutríciou, obezitou a kontrolnáskupina zdravých detí) sérové koncentrácie leptínu a porovnali ich s nutričnými a antropometrickými parametrami(BMI, SD BMI, albumín, prealbumín, transferín). Signifikantne vyšší leptín zistili u obéznych detí (p < 0,001)a u detí s chronickou renálnou insuficienciou (CHRI) v porovnaní so zdravými deťmi (p < 0,01).U zdravých dievčatbol leptín vyšší ako u zdravých chlapcov (p < 0,01). Chorí s CHRI mali vyššie hodnoty leptínu ako deti potransplantácii obličiek (p < 0,05). V skupine detí s CHRI leptín koreloval s kreatinémiou (r = 0,479, p < 0,01)a s antropometrickými ukazovateľmi SD BMI (r = 0,693, p < 0,001), BMI (r = 0,653, p < 0,001) a prealbumínom(r = 0,385, p < 0,05). U zdravých detí leptín koreloval s SD BMI (r = 0,685, p < 0,01).Autori potvrdili vyššie hodnoty leptínu u chorých s chronickou renálnou insuficienciou a u obéznych. Súdia, žehyperleptinémia pri chronickom renálnom zlyhaní je spôsobená poruchou eliminácie leptínu obličkami.
Klíčová slova:
leptín, chronická renálna insuficiencia, obezita, detský vek
Authors:
M. Salzerová 1; Ľ. Podracká 1; T. Baltesová 1; A. Feketeová 1; H. Hrbková 2; M. Jarčušková 1; M. Hricová 1
Authors‘ workplace:
Klinika detí a dorastu LF UPJŠ a FNsP, Košice, 1 prednostka prof. MUDr. Ľ. Podracká, CSc. Združená tkanivová banka LF UPJŠ a FNsP, Košice, 2 prednosta MVDR. J. Rosocha, CSc.
Published in:
Čes-slov Pediat 2002; (11): 619-623.
Category:
Overview
Leptin is a protein hormone formed mainly in adipocytes and excreted by the kidneys. Hypoleptinaemia isassociated with a reduction of body fat percentage and is found in malnutrition and endurance sports. Hyperleptinaemiais found in patients with chronic renal insufficiency and in obese subjects. The authors examined ina group of 80 children (patients with chronic renal insufficiency, malnutrition, obesity and in a control group ofhealthy children) serum leptin concentrations and compared them with nutritional and anthropometric parameters(BMI, SD, BMI, albumin, prealbumin, transferrin). Significantly higher leptin values were recorded in obesechildren (p < 0.001) and in children with chronic renal insufficiency (CHRI) as compared with healthy children (p< 0.01). In healthy girls the leptin level was higher than in healthy boys (p < 0.01). Patients with CHRI had higherleptin levels than children after transplantation of the kidneys (p < 0.05). In the group of children with CHRI leptincorrelated with creatinaemia (r = 0.479, p < 0.01) and with anthropometric indicators SD BMI (r = 0.693, p
Key words:
leptin, chronic renal insufficiency, obesity, childhood
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2002 Issue 11
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