Seasonal Incidence of Diabetes Mellitus Type 1 in Relation to Coxsackie Infection Assessed du-ring Manifestation of the Disease
Sezonalita incidencie diabetes mellitus 1. typu vo vzťahu kucoxsackie infekcii zisťovanej pri manifestácii ochorenia
Bola vyšetrená incidencia IDDM u 1369 detských diabetikov na Slovensku registrovaných od roku 1985 doroku 1997. Počiatočná incidencia bola 6,75 na 100 000 detí, o 12 rokov bol zistený vzostup na 11,40/10 5 . Chrono-biometrickou analýzou bol stanovený všeobecne vzostupný trend IDDM (koeficient lineárnej regresie b =+0,43/rok), s predikciou 13,5/10 5 pre rok 2000.Rozloženie incidencie IDDM počas roku vykazovalo sezonalitu - kumuláciu nových pacientov na jeseň a v zime,s minimom v letných mesiacoch. Sezonalita bola prítomná vo všetkých vekových skupinách.U 66 detí s manifestáciou IDDM v rokoch 1985 - 1989 sme našli významne vyššiu (58 %) prítomnosť infekcievírusom coxsackie ako u 218 zdravých kontrol (6 %). Bol preto študovaný vzťah incidencie IDDM k sérologickyvyšetrenej infekcii coxsackie.Zo súboru 179 diabetikov v rokoch 1990 - 1994 boli u 77 sérologicky anticoxsackie pozitívnych zistené maximáincidencie diabetu na jeseň a v zime, kým 102 anticoxsackie negatívnych malo vrchol incidencie IDDM na jar.U 554 zdravých detí v rokoch 1985 - 1989 vrcholila anticoxsackie sérologická pozitivita najčastejšie v lete a najeseň, teda o 3 mesiace skôr ako incidencia IDDM u našich anticoxsackie pozitívnych chorých.
Klíčová slova:
incidencia diabetu 1. typu, sekulárny trend vývoja diabetu, sezonalita incidencie IDDM,sezonalita coxsackie infekcie
Authors:
D. Michalková; A. Petrovičová 1; M. Mikulecký 1; P. Hlava 2; Sílešová J.epidemiologická Pracovní Skupina Detských Endokrinológov V Sr
Authors‘ workplace:
Detské diabetologické centrum pri I. detskej klinike DFNsP, Bratislava, prednostka doc. MUDr. M. Benedeková, CSc. Ústav preventívnej a klinickej medicíny, Bratislava, 1prednosta prof. MUDr. T. Trnovec, DrSc. Národné centrum podpory zdravia, Bratislava, 2r
Published in:
Čes-slov Pediat 1999; (9): 477-481.
Category:
Overview
The authors examined the incidence of IDDM in 1369 child diabetics in Slovakia recorded between 1985 and1997. The initial incidence was 6.75 per 100 000 children, within 12 years an increase to 11.40/10 5 was recorded.By chronobiometric analysis a general rising trend of IDDM was found (linear regression coefficient b =+0.43/year), with a prediction of 13.5/10 5 for the year 2000.The distribution of the IDDM incidence throughout the year was seasonal with cumulation of new patients inautumn and winter and a minimum during the summer months. The seasonality was apparent in all age groups.In 66 children with manifest IDDM in 1985 - 1989 we found a significantly (58%) higher presence of coxsackievirus infection than in 218 healthy controls (6%). The relationship between IDDM incidence and serologicallyassessed coxsackie infection was therefore investigated.From a group of 179 diabetics in 1990 - 1994 in 77 anticoxsackie positive ones a maximum incidence of diabetesin autumn and winter was found, while 102 anticoxsackie negative patients had the peak incidence in spring. In554 healthy children in 1985 - 1989 the anticoxsackie serological positivity had its peak most frequently in summerand autumn, i.e. 3 months earlier than the incidence of IDDM in our anticoxsackie positive patients.
Key words:
incidence of diabetes type 1, secular trend of diabetes, seasonal character of IDDM incidence,seasonal character of coxsackie infection
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
1999 Issue 9
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