Secondary Amyloidosis in a Patient with Gouty Arthritis
Sekundární amyloidóza u pacientas dnavou artritidou
Autoři popisují případ 45letého muže se čtyřletou anamnézou chronické tofózní dny. U nemocnéhobyla zjištěna proteinurie a chronická renální insuficience a z biopsie ledvin diagnostikována AAamyloidóza. Vzhledem k nálezu paraproteinu (IgGk) v séru, bylo uvažováno o myelomu, který všaknebyl potvrzen, a proto byl stav uzavřen jako benigní monoklonální gamapatie (MGUS). Výskyt AAamyloidózy je u dny vzácný a bylo zatím popsáno jen několik případů. U našeho pacienta však budenutné sledovat event. vývoj MGUS a potenciální vztahy k AA amyloidóze.
Klíčová slova:
dna, AA amyloidóza, benigní monoklonální gamapatie
Authors:
A. Pavelková; J. Gatterová; M. Merta 1; Stejskalová; . 2; Z. Vernerová 2; K. Pavelka
Authors‘ workplace:
Revmatologický ústav, Praha 1 I. interní klinika 1. LF, VFN, Praha 2 I. patologicko-anatomický ústav 1. LF UK, Praha
Published in:
Čes. Revmatol., , 2000, No. 2, p. 72-75.
Category:
Overview
The authors describe the case of a 45-year-old man with a four-year history of chronic tophaceousgout. The patient suffered from proteinuria and chronic renal failure, and from renal biopsy AAamyloidosis was diagnosed. With regard to the finding of paraprotein (IgGk) in serum, a myelomawas suspected but was not confirmed and therefore it was concluded that benign monoclonalgammapathy (MGUS) is involved. The occurrence of AA amyloidosis in gout is rare and so far onlya few cases were described. In the mentioned patient it will be however necessary to follow up thepossible development of MGUS and potential relations to AA amyloidosis.
Key words:
gout, amyloidosis, benign monoclonal gammapathy
Labels
Dermatology & STDs Paediatric rheumatology RheumatologyArticle was published in
Czech Rheumatology
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