Depression and Multiple Sclerosis (A Review of theLiterature and a Case Report)
Depresia a roztrúsená mozgomiechová skleróza(Sclerosis Multiplex)(Prehľad literatúry a kazuistiky)
Súhrn:
Depresia sa u chorých s roztrúsenou mozgomiechovou sklerózou prejaví až v polovici prípadov.Riziko samovražedného konania je to vyššie ako u depresie bez organického podkladu.Kvalita života aj funkčné schopnosti pacienta sú depresiou pri základnom neurologickom ochoreníďalej zhoršované. V článku popisujeme prípad tridsaťročnej ženy, ktorá sclerosis multiplex trpíuž sedem rokov a depresia je prítomná po dobu piatich rokov. Liečba paroxetínom skončila neúspešnea ďalšie terapeutické pokusy narážajú na pasivitu a odovzdanosť chorej. V diskusii uvažujemeo etiológii depresívnej symptomatiky najmä vo vzťahu k liečbe interferónom beta-1b.Literárne poznatky svedčia skôr proti kauzálnej súvislosti podávania imunomodulačnej látkya rozvoja afektívnej poruchy. Na záver popisujeme ďalšie možné postupy pri liečbe depresie.
Klíčová slova:
roztrúsená mozgomiechová skleróza, depresia, liečba, interferón.
Authors:
I. Dóci; L. Hosák 1; M. Kovářová 2
Authors‘ workplace:
Psychiatrická klinika Lekárskej fakulty UPJŠ a FNsP, Košice Psychiatrická klinika Lékařské fakulty UK a FN, Hradec Králové, přednosta prof. MUDr. J. Libiger, CSc. Ústav sociálneho lekárstva Lekárskej fakulty UPJŠ, Košice
2
Published in:
Čes. a slov. Psychiat., , 2003, No. 6, pp. 331-336.
Category:
Overview
Up to a half of the multiple sclerosis patients also suffer from depression. The risk of a suicidalbehavior in these subjects is increased as compared with „non-organic“ depression. At the sametime, depression further deteriorates the patients’ quality of life and his/her disability in additionto the primary neurological disorder. In the presented article, we describe a case of a thirty-yearsoldwoman who has suffered from multiple sclerosis for seven years, and a commorbid depressionhas been present for five years. The treatment with paroxetine proved unsuccessful. Passivity andresignation of the patient represent a barrier from a further therapeutic effort. In the discussionsection, we consider etiology of the depicted depressive symptoms especially as for the treatmentwith interferon beta-1b. The literary knowledge rather testifies against a causal relationshipbetween the administration application of an immunomodulatory agent and an occurance ofa mood disorder in multiple sclerosis. We mention other therapeutic possibilities at the end of thepaper.
Key words:
multiple sclerosis, depression, treatment, interferon.
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
2003 Issue 6
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