Discontinuation syndrome
„Discontinuation syndrome“ -alebo syndróm z vysadeniaantidepresív
Syndróm z vysadenia antidepresív je fenomén známy viac desaťročí.Bol popísaný po náhlom vysadení inhibítorov monoaminoxidázy (IMAO), tri-cyklických antidepresív (TCA) a v poslednej dobe aj po náhlom prerušeníliečby inhibítormi spätného vychytávania serotonínu (SSRI). V prípade syn-drómu z vysadenia SSRI ide o komplex príznakov, ktorý sme pred tým u pa-cienta nezistili. Najčastejšie sa vyskytuje po náhlom prerušení liečby.Príznaky možno rozdeliť do piatich skupín - problémy s rovnováhou, gastro-intestinálne príznaky, chrípke podobné príznaky, senzorické poruchy a po-ruchy spánku. Jedným z faktorov, ktoré ovplyvňujú frekvenciu výskytusyndrómu z vysadenia SSRI je farmakologický profil antidepresíva a zdá sa,že dlhý biologický polčas lieku chráni pacienta pred objavením sa tohotosyndrómu.
Klíčová slova:
syndróm z vysadenia, antidepresíva, biologický polčas.
Authors:
L. Vavrušová
Authors‘ workplace:
Psychiatrická klinika IVZ, NsP Ružinov, Bratislava, prednosta MUDr. A. Rakús
Published in:
Čes. a slov. Psychiat., , 1999, No. 7, pp. 483-488.
Category:
Overview
Discontinuation syndrome is a syndrome, known by clinicians for severaldecades. The discontinuation syndrome has been observed after abrupt dis-continuation of treatment with inhibitors of monoaminoxidase, tricyclic anti-depressants and serotonin re-uptake inhibitors. The serotonin re-uptakeinhibitor discontinuation syndrome is characterised by signs and symptomsnot present previously. Cluster of five somatic symptoms have been descri-bed: disequilibrium, gastrointestinal symptoms, flu-like symptoms, sensorydisturbances, sleep disturbances. The pharmacologic profile of SSRI playsthe key role in the probability of occurrence of discontinuation syndrome.The long half-life of SSRI may prevent the appearance of discontinuationsyndrome.
Key words:
discontinuation syndrome, antidepressants, half-life.
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
1999 Issue 7
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