Isotachophoretic Determination of Desloratadine in Tablets and Syrup
Izotachoforetické stanovenie desloratadínu v tabletách a sirupe
Desloratadín bol stanovovaný v dvoch liekových formách (tablety, sirup) metódou kapilárnej izotachoforézy. Bolo preskúšaných niekoľko elektrolytových systémov s rôznym zložením a rôznym pH. Pre validáciu metódy a stanovenie desloratadínu v reálnych vzorkách boli vybrané dva elektrolytové systémy. Bola hodnotená presnosť, správnosť, linearita, robustnosť a selektivita ITP metódy pre obidva elektrolytové systémy. Predúprava vzorky pred analýzou spočívala v rozpustení a nariedení príslušnej liekovej formy s obsahom desloratadínu demineralizovanou vodou na požadovanú koncentráciu. Takto upravená vzorka bola priamo dávkovaná do prístroja.
Kľúčové slová:
kapilárna izotachoforéza – desloratadín – tablety – sirup – validácia
Authors:
P. Kubačák; P. Mikuš; I. Valášková; Emil Havránek
Authors‘ workplace:
Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej analýzy a nukleárnej farmácie
Published in:
Čes. slov. Farm., 2005; 54, 266-269
Category:
Original Articles
Overview
Desloratadine was determined in two dosage forms (tablets and syrup) with the use of the method of capillary isotachophoresis. Several electrolyte systems of varying composition and varying pH were tested. Two electrolyte systems were selected for the validation of the method and determination of desloratadine in real samples. In both electrolyte systems, the precision, correctness, linearity, robustness, and selectivity of the ITP method were evaluated. The pre-treatment of the sample prior to analysis consisted in dissolving and diluting the pertinent desloratadine-containing dosage form with demineralized water to the required concentration. This pre-treated sample was fed directly to the apparatus.
Key words:
capillary isotachophoresis – desloratadine – tablets – syrup - validation
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2005 Issue 6
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