Effect of Humectants on Pharmaceutical Availability and Rheological Properties of Loratadin- Containing Hydrogels
Vplyv humektantov na farmaceutickú dostupnosť a reologické vlastnosti hydrogélov s loratadínom
Príspevok je zameraný na formulácia antihistaminika loratadínu do hydrogélov. Hodnotenými polymérmi boli Carbopol® 980 a Vivastar® P 5000. Nakoľko nevyhnutnou súčasťou hydrogélov sú aj ďalšie farmaceutické pomocné látky zo skupiny humektantov, príspevku sa hodnotí ich vplyv (glycerolu – GL, propylénglykolu – PG a sorbitolu – SO) na štruktúrnu viskozitu a pH hydrogélov a aj farmaceutickú dostupnosť loratadínu. Na základe výsledkov štúdie sa môže konštatovať, že z hľadiska dermálnej aplikácie sú pre loratadín optimálne hydrogély následovného zloženia: 0,5% Carbopol® 980 + 5% SO a 1,5 % Vivastar® P 5000 + 5 % PG.
Kľúčové slová:
hydrogély – Carbopol® 980 - Vivastar® P 5000 – loratadín – humektanty
Authors:
Z. Capková; Z. Vitková; V. Vysokaiová
Authors‘ workplace:
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie
Published in:
Čes. slov. Farm., 2005; 54, 187-191
Category:
Original Articles
Overview
The paper examines the formulation of the antihistamine loratadin into hydrogels, the polymers under evaluation being Carbopol® 980 and Vivastar® P 5000. As other pharmaceutical auxiliary substances from the group of humectants are an indispensable component of hydrogels, the paper evaluates their influence (glycerol – GL, propylene glycol – PG, and sorbitol – SO) on the structural viscosity and pH of hydrogels as well as pharmaceutical availability of loratadin. On the basis of the results of the study it can be concluded that from the viewpoint of dermal administration of loratadin the hydrogels of the following composition are optimal: 0.5% Carbopol® 980 + 5% SO and 1.5 % Vivastar® P 5000 + 5 % PG.
Key words:
hydrogels – Carbopol® 980 – Vivastar®P 5000 – loratadin – humectants
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2005 Issue 4
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