Effect of Polymer Concentration on Rheological Properties of Carbopol® 980 Hydrogels Containing Trimecainium Chloride
Vplyv koncentrácie polyméru na reologické vlastnosti hydrogélov Carbopolu® 980 s obsahom trimekaíniumchloridu
Reologické vlastnosti majú vplyv na výrobné procesy, stabilitu i aplikovateľnosť liekovej formy, taktiež na biologickú dostupnosť liečiva. Predmetom štúdia tejto práce je sledovanie vplyvu koncentrácie Carbopolu® 980 na reologické vlastnosti hydrogélov bez a s obsahom trimekaíniumchloridu, po dobu 2, 7 a 14 dní od ich prípravy. Na základe vyhodnotenia zmien štruktúrnej viskozity v závislosti od doby merania sa dospelo k záveru, že pre formuláciu trimekaíniumchloridu do dermálnej liekovej formy je vhodná 0,5% a 1,2% koncentrácia Carbopolu® 980.
Kľúčové slová:
Carbopol® 980 – trimekaíniumchlorid – hydrogély – reologické vlastnosti
Authors:
M. Šubová; Z. Vitková; E. Cirbusová; I. Erös 1; M. Kónya 1
Authors‘ workplace:
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie
; SZTE Gyógyszertechnológiai Intézet, Szeged, Maďarsko
1
Published in:
Čes. slov. Farm., 2005; 54, 96-99
Category:
Original Articles
Overview
Rheological properties exert influence on the manufacturing processes, stability and usability of a dosage form as well as the biological availability of an active ingredient. The present paper examines the effect of Carbopol® 980 concentration on rheological properties of hydrogels with and without trimecainium chloride for a period of 2, 7, and 14 days after their preparation. On the basis of an evaluation of the changes in structural viscosity in dependence on the period of measurement, it has been concluded that for formulation of trimecainium chloride to a dermal dosage form, Carbopol® 980 concentrations of 0.5 and 1.2 % are suitable.
Key words:
Carbopol® 980 – trimecainium chloride – hydrogels – rheological properties
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
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