Enzymology of Production of Benzylisoquinoline Alkaloids
Enzymológia tvorby benzylizochinolínových alkaloidov
Prehĺadná práca sumarizuje aktuálne poznatky o enzýmoch, zúčastňujúcich sa tvorby benzylizochinolínových alkaloidov. Do tejto skupiny alkaloidov patria napríklad morfín, kodeín, tebaín a sanguinarín, ktoré majú svoje nezastupiteĺné miesto vo farmaceutickej praxi. Doteraz sa ich nedarí pripraviť synteticky s dostatočnou účinnosťou, a preto je štúdium enzymológie ich tvorby stále aktuálne. Zvláštna pozornosť sa v práci venuje poznatkom o jednotlivých enzýmoch na molekulárno-biologickej, resp. génovej úrovni. Práve tieto poznatky sú esenciálne pre prípadné zavedenie molekulárno-biologických prístupov do šľachtenia rastlín, produkujúcich terapeuticky zaujímavé benzylizochinolínové alkaloidy.
Klúčové slová:
benzylizochinolínové alkaloidy – morfínany – benzofenantridíny – Papaver somniferum L. – Eschscholtzia californica Cham.
Authors:
A. Bílková; F. Bilka; L. Bezáková
Authors‘ workplace:
Katedra bunkovej a molekulárnej biológie liečiv Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 2005; 54, 17-22
Category:
Review Articles
Overview
This review paper summarizes the current knowledge of enzymes participating in the production of benzylisoquinoline alkaloids. This group of alkaloids comprises, e.g., morphine, codeine, thebaine, and sanginarine, which have an irreplaceable position in pharmaceutical practice. For the time being, chemists have not managed to prepare them synthetically with sufficient efficacy, and therefore the study of the enzymology of their formation remains a topical problem. The paper pays particular attention to the knowledge of individual enzymes on the molecular, or gene level. This very knowledge is essential for possible introduction of molecular-genetic approaches to the cultivation of plants producing therapeutically interesting benzylisoquinoline alkaloids.
Key words:
benzylisoquinoline alkaloids – morphinans – benzophenanetridines – Papaver somniferum L. – Eschscholtzia californica Cham.
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2005 Issue 1
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