Ricin – A Plant Toxin with Possible Therapeutic Use
Ricín – rastlinný toxín s možným terapeutickým využitím
Ricín je mimoriadne toxický lektín typu RIP II. Jeho jedovatosť je možné zneužiť na teroristickéúčely, pričom nie je zatiaľ známy efektívny protijed. Mechanizmus toxického pôsobenia je zároveňštudovaný s cieľom prípravy selektívnych imunotoxínov, ktoré by sa dali použiť pri liečbe rôznychtypov rakoviny či HIV infekcie. Napriek sľubným in vitro výsledkom, nepriaznivé vedľajšie účinkyv pokusoch in vivo zatiaľ obmedzujú ich použitie v reálnej terapii.
Klíčová slova:
ricín – Ricinus communis – toxín – monoklonálna protilátka
Authors:
M. Nagy
Authors‘ workplace:
Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 2004; , 131-134
Category:
Overview
Ricin is a very toxic RIP II type lectin.As no effective antidote is known, its toxicity could be misusedin terrorist actions. The mechanism of the toxic action is currently studied for the preparation ofselective immunotoxins, which could be used in the therapy of various cancer diseases or HIVinfection. There are promising in vitro results, but some adverse in vivo effects limit the use of thesepreparations in real therapy.
Key words:
ricin – Ricinus communis – toxin – monoclonal antibody
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2004 Issue 3
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