A Study of the Anticomplementary Activity of Mahonia aquifolium Crude Extract,Bisbenzylisoquinoline Alkaloids, and Berberine
ŠTÚDIUM ANTIKOMPLEMENTOVEJ AKTIVITYEXTRAKTU MAHONIA AQUIFOLIUM MAHONIA AQUIFOLIUMBISBENZYLIZOCHINOLÍNOVÝCHALKALOIDOV A BERBERÍNU
Celkový extrakt z kôry nadzemnej časti Mahonia aquifolium sa študoval z hľadiska chemickéhozloženia a účinku na komplementový systém. Výsledky ukázali, že celkový extrakt vykazujeantikomplementovú aktivitu na aktiváciu komplementu klasickou cestou, ktorá môže súvisieťs prítomnosťou alkaloidov. Frakcia BBI alkaloidov a izolovaný hlavný protoberberínový alkaloid –berberín sa vyznačujú vyššou antikomplementovou aktivitou v porovnaní s celkovým extraktom.Výsledky ukazujú, že berberín a frakcia so zmesou BBI alkaloidov sa zúčastňujú na imunomodulačnom účinku celkového extraktu M. aquifolium.
Klíčová slova:
Mahonia aquifolium – antikomplementová aktivita – berberín – frakcia BBIalkaloidov – celkový extrakt
Authors:
D. Košťálová; M. Bukovský; H. Koščová; A. Kardošová
Authors‘ workplace:
Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava, Katedra bunkovej a molekulárnej biológie liečiv Farmaceutickej fakulty Univerzity Univezita Komenského, Chemický ústav SAV, Bratislava
Published in:
Čes. slov. Farm., 2001; , 286-289
Category:
Overview
Crude extracts obtained from the stem bark of Mahonia aquifolium have been investigated as tothe chemical composition and anticomplementary activity. The results show that their anticomplementary activity is mainly due to the alkaloid components. Especially the BBI alkaloid fraction andberberine showed a strong inhibitory effect on CH50 total hemolytic complement assay. The crudeextract of M. aquifolium was less active than berberine or the fraction BBI alkaloids. The resultsindicate that the fraction of BBI alkaloids and berberine largely account for the immunomodulatoryactivity of the crude extract of M. aquifolium.
Key words:
Mahonia aquifolium – anticomplementary activity – berberine – fraction BBIalkaloids – crude extract
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2001 Issue 6
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