Cytotoxic and Genotoxic Activity of Selected Preservative Compounds for Cosmetics

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CYTOTOXICKÁ A GENOTOXICKÁ AKTIVITA VYBRANÝCH KONZERVAČNÝCH LÁTOK PRE KOZMETICKÉ PROSTRIEDKY

Študoval sa cytotoxický a genotoxický účinok in nitro konzervačných látky pre kozmetické prostriedky JMAC TD, Bronopol, CA 24 a Euxyl K100. Z porovnania hodnót ICioo vYPlYnulo, že najvyšší cytotoxický účinok na proliferáciu fibroblastových buniek V79 a VH10 indukoval Bronopol, ktorého hodnota ICioo bola v priebehu celého pokusu 10 mg/1. Konzervačně látky CA 24 a Euxyl K100 bolí 4krát, resp. 5krát menej cytotoxické ako Bronopol (ICioo = 42, resp. 50,3 mg/1). Kompozitná konzervačná látka na báze strieborných iónov JMAC TD prejavila najnižšiu cytotoxicitu (ICloo = 150 mg/1); 15krát nižšiu ako Bronopol, 3,5krát nižšiu ako CA 24 a 3krát nižšiu ako Euxyl K100. Biocíd JMAC TD neprejavil na bakteriálnych kmeňoch Salmonella typhimurium TA 98 a TA 100 žiadnu mutagénnu aktivitu.

Klíčová slova:
cytotoxicita - genotoxicita - in ~itro metódy - konzervačné látky - kozmetické prostriedky

Authors: S. Jantová; J. Hojerová; B. Hanusová; M. Mikulášová
Authors‘ workplace: Katedra biochémie a mikrobiológie Chemicko-technologickej fakulty Slovenskej technickej univerzity, Bratislava Katedra mlieka, tukov a hygieny požívatín Chemicko-technologickej fakulty Slovenskej technickej univerzity, Bratislava
Published in: Čes. slov. Farm., 2001; , 238-242
Category:

Overview

Cytotoxic effects of the preservative compounds for cosmetics JMAC TD, Bronopol, CA 24, and Euxyl K100 esere studied. Bronopol demonstrated the highest Cyotoxic effect on the proliferation of V79 and VH10 fibroblast cell unes - the ICioo values being 10 mg/1 during the whole experiment. The preservatives CA 24 and Euxyl K100 showed 4-times and 5-times smaller Cyotoxic activity than Bronopol ICioo = 42 or 50,3 mg/1). The preservative compounds on silver chloride ions JMAC TD manifested the lowest cytotoxicity of the preservatives tested (ICioo = 150 mg/1); 15-times smaller than Bronopol, 3,5-times smaller than CA 24 and 3-times smaller than Euxyl K100. The biocide JMAC TD did not exhibit mutagenic effects on the bacteria Salmonella typhimurium TA 98 and TA 100.

Key words:
cytotoxicity - genotoxicity - in ~itro methods - preservatives - cosmetics

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Article was published in

Czech and Slovak Pharmacy

2001 Issue 5

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