Study of Local AnestheticsPart 154: Study of Micelization of the Homologs of Heptacainium Chloride
ŠTÚDIUM LOKÁLNYCH ANESTETÍKČASŤ 154: ŠTÚDIUM MICELIZÁCIEHOMOLÓGOV HEPTAKAÍNIUMCHLORIDU
Študovali sme kritickú micelárnu koncentráciu (c.m.c.) homológov lokálneho anestetika heptakaínuv roztoku 0,1 mol/l NaCl pomocou spektrofotometrie v ultrafialovej oblasti pri teplote T=21 °C a pH» 4,5-5,0. Na základe získaných experimentálnych výsledkov predpokladá sa, že v homologickýchradoch amfifilných zlúčenín za kváziparabolické závislosti biologických účinností na dľžke ichhydrofóbneho substituenta (—cut-offit efekt) je zodpovedná c.m.c.
Klíčová slova:
anestetiká - heptakaín - kritická micelárna koncentrácia (c.m.c.)
Authors:
F. Andriamainty; RIKJ. Čižmá
Authors‘ workplace:
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in:
Čes. slov. Farm., 2001; , 153-155
Category:
Overview
We have studied the critical micellar concentration (c.m.c.) of the homologs of the local anestheticheptacaine in the medium 0.1 mol/l NaCl, employing spectrophotometry in the UV region of thespectrum at T=21 °C and pH » 4.5Œ5.0. On the basis of our experimental results, it is assumed thatin the homologous series of amphiphilic compounds the quasi-parabolic dependence of biologicalpotencies on the length of their hydrophobic substituent (—cut-offit effect) could be caused by c.m.c.
Key words:
local anesthetic - heptacaine - critical micellar concentration (c.m.c.)
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2001 Issue 3
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