Intraocular Pressure in Rabbits after Addition of the 10% L-arginin.HCl, to the 2%Trusopt
Vnútroočný tlak králikov po aplikácii10% L-arginínu.HCl v 2% Trusopte
Vpráci sa predkladá zistenie, že pridanie 10%L-arginin.HClk 2%Trusoptu zvyšujeaktivitu antiglaukomatika prejavujúca sa signifikantným znížením VOT u králikovNovo Zelandský biely s normálnym vnútroočným tlakom, a to od 15 min. do240 min. v porovnaní s aplikáciou oboch látok samostatne. Veľkosť pupily saneovplyvni. Na základe našich experimentálnych výsledkov predpokladáme, žetáto zvýšená aktivita Trusoptu v zmesi s aminokyselinou L-arginín.HCl spočívavo vzniku novéhometabolitu. Tento metabolit tým, že znižuje tvorbu komorovéhomoku a zvyšuje uveo-sklerálny odtok, spôsobuje výraznejší pokles vnútroočnéhotlaku.
Klíčová slova:
IOPpoaplikáciiaminokyseliny 10%L-arginínu.HCl,po2%Trusoptea ich zmesi
Authors:
J. Veselovský; Z. Oláh; A. Veselá; S. Gressnerová
Authors‘ workplace:
Katedra živočíšnej fyziológie a etológie Prif UK, Bratislava, SR, vedúci doc. RNDr. M. Zeman, DrSc. Klinika oftalmológie LFUK, Bratislava, SR, prednosta prof. MUDr. P. Strmeň, CSc.
Published in:
Čes. a slov. Oftal., , 2004, No. 2, p. 81-88
Category:
Overview
In this contribution publish the observation that addition of 10% L-arginin.HCl tothe 2% Trusopt eye drops intensifies activity of antiglaucomatics with an importantreduction of the normal intraocular pressure (IOP) in rabbits New Zelandwhite namely from 15 up to 240 minutes, compared with application of bothsubstance alone. Size of the pupil was not affected. Based on our experimentalresultsweassumethat this increasing activity of Trusoptmixture with amino acidL-arginin.HCl created a new metabolite. According to our observations this metabolitecaused reduction of the humor aqueous production and together with theincreased of the uveo-scleral outflow leads to the striking reduction of the IOP.
Key words:
IOP after instillation the amino acid 10% L-arginin.HCl. 2% Trusoptand mixture both of them
Labels
OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
2004 Issue 2
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