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Overuse of Corticosteroids as a Serious Problem in ITP
9. 5. 2023 Source: Immune ThrombocytopeniaCorticosteroids (CS) are a common part of the treatment for immune thrombocytopenia (ITP). However, their administration is associated with significant short-term and long-term toxicity, and the goal should be to minimize their use to the shortest possible duration. Early combination with other medications could be helpful in this regard.
Romiplostim in Life-Threatening Bleeding Situations − Case Reports
Immune thrombocytopenic purpura, or immune thrombocytopenia (ITP), typically manifests as bleeding due to a low platelet count. Some bleeding episodes can be life-threatening or fatal. Clinical…9. 5. 2023 Source: Immune Thrombocytopenia
CYP Enzyme? Cytochrome P450 2D6 and Drug Metabolism
The CYP2D6 isoenzyme of cytochrome P450 participates in the metabolism of approximately 20% of commonly used drugs. Genetic variants of this enzyme are very common, leading to significant inter-individual...5. 5. 2023 Source: Genetics
Association of M2 Haplotype of the Annexin A5 Gene with Recurrent Reproductive Losses
Annexin A5 (ANXA5) is a placental anticoagulant protein that ensures adequate blood supply to the fetus during pregnancy, and its deficiency can increase the incidence of vascular thrombosis in the…5. 5. 2023 Source: Genetics
Etiology of Recurrent Reproductive Losses – Focus on Genetics
Repeated pregnancy losses pose a significant threat to a woman's physical and mental health. The etiology of up to half of these cases remains unexplained, and recurrent reproductive losses are…4. 5. 2023 Source: Genetics
Li-Fraumeni Syndrome – Indication for Testing and Recommended Surveillance
A germline mutation of the TP53 gene, which causes Li-Fraumeni syndrome, results in a congenital predisposition to the occurrence of malignant tumors, such as pediatric malignancies, breast cancer, bone...3. 5. 2023 Source: Genetics
Water Microjet as a Gentler Method of Debridement
Debridement is an integral part of chronic wound treatment. Currently, the most common method is mechanical debridement, which involves the use of sharp tools or abrasive materials to remove necrotic…3. 5. 2023 Source: Wound Healing
INFOGRAPHIC: Eye Drops for Dry and Irritated Eyes – Mechanism of Action and Benefits
2. 5. 2023 Source: Ophthalmologic Diseases
Dravet Syndrome – Get to Know It
Dravet syndrome is a severe myoclonic epilepsy occurring in early childhood. It is classified as a rare progressive epileptic encephalopathy, characterized by generalized or lateralized clonic…2. 5. 2023 Source: Rare Diseases in Neurology
When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?
Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle weakness and fatigability that worsens after physical exertion or mental stress. Accurate diagnosis is…2. 5. 2023 Source: Rare Diseases in Neurology
Sjögren's Syndrome as a Cause of Dry Eye Syndrome
Primary Sjögren's syndrome represents a complex autoimmune disease primarily affecting glands with exocrine secretion. Dry eye syndrome ranks among the most common difficulties for patients with…2. 5. 2023 Source: Ophthalmologic Diseases
Infographic and Commentary from Practice: Reasons and Pathways for Patients to Biological Treatment of Asthma
For asthma patients with the most severe forms of the disease to access targeted biological treatment, they must undergo examination at one of the specialized centers for severe asthma. To facilitate…
Subcutaneous pdC1-INH in Patients with Hereditary Angioedema in Real-World Practice
Italian authors published a series of cases of patients with hereditary angioedema caused by C1 inhibitor deficiency (C1-INH-HAE) with long-term prophylaxis using human plasma-derived C1 inhibitor concentrate...27. 4. 2023 Source: Hereditary Angioedema
Efficacy and Safety of an Activated FXII Inhibitor in Preventing HAE Attacks
Hereditary angioedema (HAE) is a rare, potentially life-threatening inherited disorder characterized by dysregulation of the kallikrein-kinin system. This results in excessive production of bradykinin,...27. 4. 2023 Source: Hereditary Angioedema
To what extent does the delay between symptom onset and diagnosis of AATD affect patient survival?
The risk of chronic obstructive pulmonary disease (COPD) is increased, among other things, by a deficiency of alpha-1-antitrypsin (AATD). However, there is often a delay between the onset of symptoms...26. 4. 2023 Source: Deficiency of Alpha-1-Antitrypsin
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