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Combination of SGLT2 inhibitors with metformin in terms of mechanism of action
In the treatment of type 2 diabetes (T2D), metformin is recommended as the first-line drug alongside lifestyle modification. However, with disease progression, monotherapy is often insufficient. SGLT2 inhibitors (SGLT2i) are recommended in combination with metformin in light of recent findings, as their mechanism of action is independent of insulin effect. They have shown a reduction in cardiovascular (CV) risk in diabetics with CV disease.
Immunotolerance is still the goal of management of hemophilia A with inhibitor in the era of non-factor therapy
New molecules in hemophilia therapy have raised many questions, including regarding the…
Basic Information on the Spread and Course of COVID-19 Infection in China: What We Know So Far?
Currently, we are experiencing a worldwide outbreak of COVID-19 infection caused by the SARS-CoV-2…
Rapid Diagnosis of Depression in Primary Care Settings
Depression is one of the most commonly occurring psychiatric disorders encountered in general…
The Link Between Various Sleep Disorders and the Onset of Depression: What Findings Did the Population Study in Denmark Bring?
A Danish population study published in June 2019 examined the link between different types of sleep…
Insufficient dosing of enoxaparin is common in patients post-orthopedic surgery and increases the risk of thromboembolic disease
Orthopedic and traumatological procedures involving the pelvis and lower limbs are associated with…
Dabigatran as Effective Prevention of VTE Recurrence Also in Patients with Thrombophilia
With increasing positive experience with direct oral anticoagulants, the question arises of how…
Trazodone as a Multimodal and Multifunctional Antidepressant
Substances with multiple therapeutic effects, often depending on the dose, can be described as…
Prognostic Significance of Lymphopenia for Stratification of Patients with Follicular Lymphoma
The therapy of follicular lymphoma (FL) is guided by several prognostic indices, such as the…
Benefit of Maintenance Therapy with Olaparib in Newly Diagnosed Advanced Ovarian Cancer
The SOLO-1 study evaluated whether the use of the PARP inhibitor olaparib in the maintenance…