Pancreatic tumors continue to be a challenge in modern oncology. Due to the asymptomatic nature of early stages, most cases are diagnosed in advanced stages. The five-year survival rate of patients does not even reach 10%, and up to half of patients with metastatic pancreatic cancer never make it to the second line of systemic therapy due to the rapid deterioration of their overall clinical condition. In a case study from her own practice, Dr. Marie Beneš Kočová from the Oncology Department of České Budějovice Hospital shared her experience…

Dostupná data ukazují, že profylaxe enoxaparinem účinně snižuje výskyt žilní tromboembolie (VTE), a to bez významného zvýšení rizika krvácení. I přes tyto důkazy se podání profylaxe u pacientů po traumatu často přerušuje, zejména kvůli chirurgickým výkonům. Recentně publikovaná americká studie vyčíslila souvislost mezi VTE a vynecháním dávek enoxaparinu u pacientů po úrazu nebo velké operaci.

Nízkomolekulární hepariny jsou zlatým standardem antitrombotické profylaxe u chirurgických i interních pacientů. Od roku 2016 je v EU registrován první biosimilární enoxaparin – Inhixa. Italská studie přináší výsledky hodnocení jeho účinnosti a bezpečnosti v prevenci žilní tromboembolie v reálné klinické praxi i jejich porovnání se sdruženými daty u srovnatelné populace pacientů z klinických studií s originálním enoxaparinem.

Von Willebrand Disease (vWD), as the most common congenital bleeding disorder, remains underdiagnosed. However, thanks to new insights and advances in genetic testing, both diagnosis and long-term prophylaxis of the disease are gradually improving, leading to a significant reduction in bleeding and better quality of life for patients. We discuss this in more detail with MD Eva Drbohlavová from the Department of Clinical Hematology at the Regional Hospital Liberec.

Just like in other fields of medicine, artificial intelligence (AI) has been experiencing a significant boom in dental medicine recently. It finds use in several areas here – diagnosis, treatment planning, or predicting possible outcomes. The following paragraphs will focus on a brief overview of specific activities where artificial intelligence can help dentists in the future.

Inflammation plays a role at various stages of the cardiovascular (CV) continuum, in both atherosclerotic and non-atherosclerotic CV diseases. Where to look for inflammation in the pathophysiology of CV diseases, why inflammation is related to aging, and how to utilize these findings in clinical practice was explained in a lecture by MUDr. Peter Wohlfahrt, Ph.D., from the Center of Preventive Cardiology IKEM in Prague, at the XXXII Annual Meeting of the Czech Cardiology Society.

Secondary antibody immunodeficiency is a common complication in patients with chronic lymphocytic leukemia (CLL), and infections, along with secondary malignancies, are the leading cause of death in these patients. Hypogammaglobulinemia can be managed with immunoglobulin replacement therapy (IGRT). Besides the classic intravenous form (IVIG), a subcutaneous form (SCIG) is also available. An Italian retrospective study published in the journal Current Oncology compared their efficacy in secondary immunodeficiency in CLL patients.